The higher order organization of eukaryotic and prokaryotic genomes is pivotal in the
regulation of gene expression. Specifically, chromatin accessibility in eukaryotes and …

Unlike the nuclear genome, the mammalian mitochondrial genome (mtDNA) is thought to be
coated solely by mitochondrial transcription factor A (TFAM), whose binding sequence …

Human mitochondrial DNA (mtDNA) is believed to lack chromatin and histones. Instead, it is
coated solely by the transcription factor TFAM. We asked whether mtDNA packaging is more …

Cellular metabolism relies on the regulation and maintenance of mitochondrial DNA
(mtDNA). Hundreds to thousands of copies of mtDNA exist in each cell, yet because …

The mammalian mitochondrial transcription factor A (TFAM) is encoded in the nucleus and
imported into mitochondria, where it functions as an activator of mtDNA transcription and …

Mitochondria contain a 16.6 kb circular genome encoding 13 proteins as well as
mitochondrial tRNAs and rRNAs. Copies of the genome are organized into nucleoids …

Mitochondria, the only semiautonomous organelles in mammalian cells, possess a circular,
double-stranded genome termed mitochondrial DNA (mtDNA). While nuclear genomic DNA …

Mitochondrial DNA (mtDNA) genes are long known to be cotranscribed in polycistrones, yet
it remains impossible to study nascent mtDNA transcripts quantitatively in vivo using existing …

Transcription of mitochondrial DNA (mtDNA)-encoded genes is thought to be regulated by a
handful of dedicated transcription factors (TFs), suggesting that mtDNA genes are separately …

Human mitochondrial DNA (mtDNA) is a 16.6-kb circular genome that is typically found in∼
1000 copies per cell. Frequently, one or more forms of mtDNA (ie wildtype (WT) and one or …