Alzheimer's disease (AD) is one of the foremost neurodegenerative diseases, characterized
by beta-amyloid (Aβ) plaques and significant progressive memory loss. In AD, astrocytes are …

Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Impaired
neuronal bioenergetics and neuroinflammation are thought to play key roles in the …

Mitochondria in neurons generate adenosine triphosphate (ATP) to provide the necessary
energy required for constant activity. Nicotinamide adenine dinucleotide (NAD+) is a vital …

Nicotinamide adenine dinucleotide (NAD+) is an important natural molecule involved in
fundamental biological processes, including the TCA cycle, OXPHOS, β-oxidation, and is a …

There is a dire need to discover new targets for Alzheimer's disease (AD) drug development.
Decreased neuronal glucose metabolism that occurs in AD brain could play a central role in …

Aβ exerts prooxidant or antioxidant effects based on the metal ion concentrations that it
sequesters from the cytosol; at low metal ion concentrations, it is an antioxidant, whereas at …

Apolipoprotein E4 (ApoE4) is the most recognized genetic risk factor for late-onset
Alzheimer's disease (LOAD), whereas ApoE2 reduces the risk for LOAD. The underlying …

Background Mitochondrial dysfunction is a hallmark of neurodegenerative diseases
including Alzheimer's disease (AD), with morphological and functional abnormalities limiting …

The neuroprotective role of adenosine and the deregulation of adenosine receptors in
Alzheimer's disease (AD) have been extensively studied in recent years. However, little is …

Urate has emerged as a promising target for neuroprotection based on epidemiological
observations, preclinical models, and early clinical trial results in multiple neurologic …