The inflammatory bowel diseases (IBD) comprise complex genetic disorders, with multiple
contributing genes. Linkage studies have implicated several genomic regions as likely …

Strong epidemiological evidence for a genetic contribution to pathogenesis in inflammatory
bowel disease (IBD) has stimulated efforts to identify susceptibility genes for both of its major …

The identification of the role of genetic variants within NOD2 (CARD15) in Crohn's disease
and ulcerative colitis susceptibility highlight the role of the innate immune system in …

The inflammatory bowel diseases (IBD) are comprised of two major subphenotypes, Crohn's
disease (CD) and ulcerative colitis (UC). A significant role for genetic factors in IBD was …

There is a general consensus that interplay of genetic and environmental factors leads to an
overactive mucosal immune response, which mediates the tissue damage in inflammatory …

Great progress in the understanding of the molecular genetics of inflammatory bowel
disease (IBD) has been made over the last 10 years. Strong epidemiological evidence …

The search for susceptibility genes had its first success in 1996, when the first susceptibility
locus for CD was identified in the pericentromeric region of chromosome 16, which was …

The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various
environmental and host (eg genetic-, epithelial-, immune and non-immune) factors are …

Twin studies and large-scale population studies have confirmed an increased sibling risk for
both Crohn's disease (CD) and ulcerative colitis (UC). Unlike single gene disorders, CD and …

Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by
chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent …