Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors
are strongly associated with its development; however, recently it has been observed that …

Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

OBJECTIVE: To review the current knowledge of the mechanism of DNA methylation, its
association with transcriptional silencing, possible mechanisms of hyper-and …

Introduction Osteoarthritis (OA) is a chronic musculoskeletal disease characterized by
progressive loss of joint function. Historically, it has been characterized as a disease caused …

Osteoarthritis (OA) is a prevalent disease of articular joints and primarily characterized by
degradation and calcification of articular cartilage. Presently, no effective treatment other …

Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …

Abstract Purpose of Review Epigenomics has emerged as a key player in our rapidly
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …

A variety of osteoarticular conditions possess an underlying genetic aetiology. Large-scale
genome-wide association studies have identified several genetic loci associated with …

Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …

Background The elderly population is at risk of osteoarthritis (OA), a common, multifactorial,
degenerative joint disease. Environmental, genetic, and epigenetic (such as DNA …