Chemokine G-protein coupled receptors are validated drug targets for many diseases,
including cancer, neurological, and inflammatory disorders. Despite much time and effort …

The number of known potential drug targets within the chemokine system has expanded in
the last decade with the characterization of new chemokines and chemokine receptors …

Chemokines and their receptors are involved in the pathogenesis of diseases ranging from
asthma to AIDS. Chemokine receptors are G-protein-coupled serpentine receptors that …

Chemokines are a family of around 40 small proteins, which are secreted by a variety of
cells, including structural cell types and leukocytes of the immune system. Chemokines bind …

Chemokine receptors are widely expressed on a variety of immune cells and play a crucial
role in normal physiology as well as in inflammatory and infectious diseases. The existence …

Chemokine receptor antagonists that held much promise for the treatment of autoimmune
and inflammatory diseases have recently performed poorly in clinical trials, resulting in …

Importance of the field: Chemokine receptors are most noted for their role in cell migration.
However, inappropriate utilization or regulation of these receptors is implicated in many …

Chemokines are critical mediators of cell migration during routine immune surveillance,
inflammation, and development. Chemokines bind to G protein–coupled receptors and …

Chemokine receptors belong to one of the most pharmacologically exploited proteins, the G-
protein-coupled receptors. Drugs that target these receptors make up greater than 45% of all …

In the human chemokine system, interactions between the approximately 50 known
endogenous chemokine ligands and 20 known chemokine receptors (CKRs) regulate a …