While inflammation induced by Toll-like receptor (TLR) signaling is required to combat
infection, persistent inflammation can damage host tissues and contribute to a myriad of …

Although a robust inflammatory response is needed to combat infection, this response must
ultimately be terminated to prevent chronic inflammation. One mechanism that terminates …

Inflammation driven by Toll-like receptor (TLR) signaling pathways is required to combat
infection. However, inflammation can damage host tissues; thus it is essential that TLR …

The innate immune response plays a key role in fighting infection by activating inflammation
and stimulating the adaptive immune response. However, chronic activation of innate …

Background Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr)
cascade has been shown to dramatically alter the signaling capacity of inflammatory cells …

Toll-like receptor 8 (TLR8) senses single-stranded RNA (ssRNA) and initiates innate
immune responses. TLR8 requires proteolytic cleavage at the loop region (Z-loop) between …

Toll-like receptors (TLRs) play critical roles in bridging the innate and adaptive immune
responses. The human TLR3 recognizes foreign-derived double-stranded RNA and …

Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …

Inflammation is vital to protect the host against foreign organism invasion and cellular
damage. It requires tight and concise gene expression for regulation of pro-and anti …

Toll-like receptors (TLRs) are pivotal components of the innate immune response, which is
responsible for eradicating invading microorganisms through the induction of inflammatory …