The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

L Bingle, NJ Brown, CE Lewis - … of Pathology: A Journal of the …, 2002 - Wiley Online Library
The role of macrophages in tumour growth and development is complex and multifaceted.
Whilst there is limited evidence that tumour‐associated macrophages (TAMs) can be directly …

[HTML][HTML] Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

S Zhu, M Yi, Y Wu, B Dong, K Wu - Experimental Hematology & Oncology, 2021 - Springer
Macrophages are heterogeneous cells that present as different functional phenotypes due to
their plasticity. They can be classified into two categories, namely M1-and M2-like …

[HTML][HTML] Tumor-associated macrophages, potential targets for cancer treatment

L Yang, Y Zhang - Biomarker research, 2017 - Springer
The fact that various immune cells, including macrophages, can be found in tumor tissues
has long been known. With the introduction of concept that macrophages differentiate into a …

Role of macrophages in tumour progression

KS Siveen, G Kuttan - Immunology letters, 2009 - Elsevier
It is now becoming clear that the inflammatory cells that exist in the tumour
microenvironment play an indispensable role in cancer progression. Tumour associated …

Tumour-associated macrophages as treatment targets in oncology

A Mantovani, F Marchesi, A Malesci, L Laghi… - Nature reviews Clinical …, 2017 - nature.com
Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …

Tumor-associated macrophages: effectors of angiogenesis and tumor progression

SB Coffelt, R Hughes, CE Lewis - … et Biophysica Acta (BBA)-Reviews on …, 2009 - Elsevier
Tumor-associated macrophages (TAMs) are a prominent inflammatory cell population in
many tumor types residing in both perivascular and avascular, hypoxic regions of these …

Role of tumour-associated macrophages in cancer-related inflammation.

A Sica - Experimental oncology, 2010 - europepmc.org
The construction of an inflammatory microenvironment provides the fuel for cancer
development and progression. Hence, solid tumors promote infiltration of leukocyte …

Therapeutic manipulation of tumor-associated macrophages: facts and hopes from a clinical and translational perspective

P Allavena, C Anfray, A Ummarino, FT Andón - Clinical Cancer Research, 2021 - AACR
The stroma of most solid tumors is populated by myeloid cells, which mostly represent
macrophages. Tumor-associated macrophages (TAMs), strongly influenced by cancer cell …

Tumor-associated macrophages: functional diversity, clinical significance, and open questions

SK Biswas, P Allavena, A Mantovani - Seminars in immunopathology, 2013 - Springer
Inflammation is now a well-recognized hallmark of cancer progression. Tumor-associated
macrophages (TAMs) are one of the major inflammatory cells that infiltrate murine and …

Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

P Allavena, A Mantovani - Clinical & Experimental Immunology, 2012 - academic.oup.com
Summary OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW
SERIES Metabolic Diseases, Host Responses, Allergies, Autoinflammatory Diseases, Type …