Abstract N-methyl-d-aspartate (NMDA) receptor (NMDAR) hypofunction plays a key role in
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …

The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …

Schizophrenia (SZ) is a neurodevelopmental disorder with cognitive deficits manifesting
during early stages of the disease. Evidence suggests that genetic factors in combination …

Schizophrenia is a disabling mental illness that is now recognized as a neurodevelopmental
disorder. It is likely that genetic risk factors interact with environmental perturbations to affect …

The N-methyl-d-aspartate receptor hypofunction is one of the most prevalent models of
schizophrenia. For example, healthy subjects treated with uncompetitive N-methyl-d …

Hypofunction of N-methyl-d-aspartic acid-type glutamate receptors (NMDAR) induced by the
systemic administration of NMDAR antagonists is well known to cause schizophrenia-like …

N-methyl-d-aspartic acid receptor (NMDAR) hypofunction has long been implicated in
schizophrenia and NMDARs on γ-aminobutyric acid (GABA) ergic interneurons are …

N‐methyl‐d‐aspartate receptors (NMDARs) play a pivotal role in excitatory
neurotransmission, synaptic plasticity and brain development. Clinical and experimental …

While the dopamine hypothesis has dominated schizophrenia research for several decades,
more recent studies have highlighted the role of fast synaptic transmitters and their receptors …

Highlights•NMDA receptor (NMDAR) hypofunction contributes to the etiology of
schizophrenia.•Serine racemase, a risk gene for schizophrenia, is expressed primarily in …