Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

Inflammation in the tumor microenvironment is now recognized as one of the hallmarks of
cancer. Endogenously produced lipid autacoids, locally acting small molecule lipid …

Emerging on the horizon in cancer therapy is an expansion of the scope of treatment beyond
cytotoxic approaches to in clude molecular management of cancer physiopathology. The …

Discovery of molecular pathways critical to carcinogenesis is revolutionizing the treatment
and prevention of cancer. Traditional chemotherapeutic approaches usually cause'global' …

Smoldering, nonresolving inflammation is a component of the tumor microenvironment. The
linkage between inflammation and cancer, first perceived in the nineteenth century, is now …

Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that
have been implicated in various pathological processes, such as inflammation and cancer …

Inflammation and angiogenesis in the tumor microenvironment are increasingly implicated
in tumorigenesis. Endogenously produced lipid autacoids, locally acting small-molecule …

Chronic infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and high-
calorie diet have been recognized as major risk factors for the most common types of cancer …

Toxic environmental carcinogens promote cancer via genotoxic and nongenotoxic
pathways, but nongenetic mechanisms remain poorly characterized. Carcinogen-induced …

There are clear links between chronic inflammation and cancer; strong epidemiological and
genetic evidence indicates that inflammation can drive tumour progression, and more-recent …