Circulating dipeptidyl peptidase 3 is a myocardial depressant factor: dipeptidyl peptidase 3 inhibition rapidly and sustainably improves haemodynamics
Aims Acute heart failure is a high mortality disease and its pathophysiology is not completely
understood. Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in angiotensin II …
understood. Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in angiotensin II …
Circulating dipeptidyl peptidase 3 and alteration in haemodynamics in cardiogenic shock: results from the OptimaCC trial
Abstract Aims Dipeptidyl peptidase 3 (DPP3) is a protease involved in the degradation of
cardiovascular mediators. Its administration has been shown to be associated with impaired …
cardiovascular mediators. Its administration has been shown to be associated with impaired …
Dipeptidyl peptidase-4 modulates left ventricular dysfunction in chronic heart failure via angiogenesis-dependent and-independent actions
T Shigeta, M Aoyama, YK Bando, A Monji, T Mitsui… - Circulation, 2012 - Am Heart Assoc
Background—The inhibition of dipeptidyl peptidase-4 (DPP4) protects the heart from acute
myocardial ischemia. However, the role of DPP4 in chronic heart failure independent of …
myocardial ischemia. However, the role of DPP4 in chronic heart failure independent of …
Circulating dipeptidyl peptidase IV activity correlates with cardiac dysfunction in human and experimental heart failure
L dos Santos, TA Salles, DF Arruda-Junior… - Circulation: Heart …, 2013 - Am Heart Assoc
Background—The present study addresses the hypothesis that the activity of dipeptidyl
peptidase IV (DPPIV), an enzyme that inactivates peptides that possess cardioprotective …
peptidase IV (DPPIV), an enzyme that inactivates peptides that possess cardioprotective …
Inhibition of circulating dipeptidyl-peptidase 3 restores cardiac function in a sepsis-induced model in rats: a proof of concept study
Sepsis is a global economic and health burden. Dipeptidyl peptidase 3 (DPP3) is elevated
in the plasma of septic patients. The highest levels of circulating DPP3 (cDPP3) are found in …
in the plasma of septic patients. The highest levels of circulating DPP3 (cDPP3) are found in …
The emerging role of dipeptidyl peptidase 3 in pathophysiology
G Malovan, B Hierzberger, S Suraci… - The FEBS …, 2023 - Wiley Online Library
Dipeptidyl peptidase 3 (DPP3), a zinc‐dependent aminopeptidase, is a highly conserved
enzyme among higher animals. The enzyme cleaves dipeptides from the N‐terminus of tetra …
enzyme among higher animals. The enzyme cleaves dipeptides from the N‐terminus of tetra …
Dipeptidyl peptidase 4 inhibition alleviates shortage of circulating glucagon-like peptide-1 in heart failure and mitigates myocardial remodeling and apoptosis via the …
M Aoyama, H Kawase, YK Bando, A Monji… - Circulation: Heart …, 2016 - Am Heart Assoc
Background—Ample evidence demonstrates cardiovascular protection by incretin-based
therapy using dipeptidyl peptidase 4 inhibitor (DPP4i) and glucagon-like peptide-1 (GLP-1) …
therapy using dipeptidyl peptidase 4 inhibitor (DPP4i) and glucagon-like peptide-1 (GLP-1) …
Dipeptidyl peptidase inhibition prevents diastolic dysfunction and reduces myocardial fibrosis in a mouse model of Western diet induced obesity
Objective Consumption of a high-fat/high-fructose Western diet (WD) is linked to rising
obesity and heart disease, particularly diastolic dysfunction which characterizes early …
obesity and heart disease, particularly diastolic dysfunction which characterizes early …
Dipeptidyl peptidase 4 as a therapeutic target in ischemia/reperfusion injury
V Matheeussen, W Jungraithmayr… - Pharmacology & …, 2012 - Elsevier
Dipeptidyl peptidase 4 (DPP4, DPPIV, CD26, EC 3.4. 14.5) was discovered more than four
decades ago as a serine protease that cleaves off N-terminal dipeptides from peptide …
decades ago as a serine protease that cleaves off N-terminal dipeptides from peptide …
Sitagliptin reduces inflammation, fibrosis and preserves diastolic function in a rat model of heart failure with preserved ejection fraction
G Esposito, D Cappetta, R Russo… - British Journal of …, 2017 - Wiley Online Library
Background and Purpose Heart failure with preserved ejection fraction (HFpEF) is a
systemic syndrome driven by co‐morbidities, and its pathophysiology is poorly understood …
systemic syndrome driven by co‐morbidities, and its pathophysiology is poorly understood …