Restless legs syndrome: from pathophysiology to clinical diagnosis and management

S Guo, J Huang, H Jiang, C Han, J Li, X Xu… - Frontiers in aging …, 2017 - frontiersin.org
Restless legs syndrome (RLS), a common neurological sensorimotor disorder in western
countries, has gained more and more attention in Asian countries. The prevalence of RLS is …

[HTML][HTML] Restless legs syndrome: current concepts about disease pathophysiology

BB Koo, K Bagai, AS Walters - Tremor and Other Hyperkinetic …, 2016 - ncbi.nlm.nih.gov
Background In the past few decades, much has been learned about the pathophysiology of
restless legs syndrome (RLS). Investigators have studied neuropathology, imaging …

Restless legs syndrome

M Manconi, D Garcia-Borreguero… - Nature reviews Disease …, 2021 - nature.com
Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge
to move that appears during rest or is exacerbated by rest, that occurs in the evening or night …

Recent advances in the diagnosis, genetics and treatment of restless legs syndrome

C Trenkwalder, B Högl, J Winkelmann - Journal of neurology, 2009 - Springer
Abstract Knowledge of restless legs syndrome (RLS) has greatly increased in recent years
due to the many advances that have been made in diagnosis, management and genetics …

The restless legs syndrome

G Barriere, JR Cazalets, B Bioulac, F Tison… - Progress in …, 2005 - Elsevier
The restless legs syndrome (RLS) is one of the commonest neurological sensorimotor
disorders at least in the Western countries and is often associated with periodic limb …

Restless leg syndrome: is it a real problem?

PE Cotter, ST O'Keeffe - Therapeutics and Clinical Risk …, 2006 - Taylor & Francis
Restless legs syndrome (RLS) is a common condition that is frequently unrecognized,
misdiagnosed and poorly managed. It is characterized by uncomfortable sensations deep in …

New paradigms in the treatment of restless legs syndrome

MJ Thorpy - Neurology, 2005 - AAN Enterprises
Restless legs syndrome (RLS) is a common neurologic disorder occurring in 3% to 15% of
the general population, which contributes to poor quality of life. Many patients go …

An update on the pathophysiology and genetics of restless legs syndrome

LM Trotti, S Bhadriraju, DB Rye - Current neurology and neuroscience …, 2008 - Springer
This update on restless legs syndrome (RLS) focuses on its pathophysiology, genetics,
health impact, and treatment. Although symptoms are exquisitely responsive to …

Pivotal role of adenosine neurotransmission in restless legs syndrome

S Ferré, C Quiroz, X Guitart, W Rea… - Frontiers in …, 2018 - frontiersin.org
The symptomatology of Restless Legs Syndrome (RLS) includes periodic leg movements
during sleep (PLMS), dysesthesias, and hyperarousal. Alterations in the dopaminergic …

Genetics of restless legs syndrome

J Winkelmann - Current neurology and neuroscience reports, 2008 - Springer
Restless legs syndrome (RLS) is a highly familial trait with heritability estimates of about
50%. It is a polygenetic disorder in which a number of variants contribute to the phenotype …