An important concept in neurobiology is “neurons that fire together, wire together” which
means that the formation and maintenance of synapses is promoted by activation of those …

Neurodegeneration in mitochondrial disorders is considered irreversible because of limited
metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial …

The production of neurons from neural progenitor cells, the growth of axons and dendrites
and the formation and reorganization of synapses are examples of neuroplasticity. These …

Mitochondria generate ATP essential for neuronal growth, function, and regeneration. Due
to their polarized structures, neurons face exceptional challenges to deliver mitochondria to …

The structure and function of neurons is dynamic during development and in adaptive
responses of the adult nervous system to environmental demands. The mechanisms that …

The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate.
Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay …

Mitochondria are associated with various cellular activities critical to homeostasis,
particularly in the nervous system. The plastic architecture of the mitochondrial network and …

Mitochondria fulfill numerous cellular functions including ATP production, Ca2+ buffering,
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …

Although the etiology for many neurodegenerative diseases is unknown, the common
findings of mitochondrial defects and oxidative damage posit these events as contributing …

Significance: The mitochondrial energy-transducing capacity is essential for the
maintenance of neuronal function, and the impairment of energy metabolism and redox …