Background Prefrontal dopamine D1 receptor (D1R) mediates behavior related to anxiety,
reward and memory, and is involved in inflammatory processes, all of which are affected in …

Background The altered expression and function of dopamine receptor D3 (D3R) in patients
and animal models have been correlated with depression disease severity. However, the …

We recently reported that dopamine D3 receptor (D3R) was involved in inflammation-related
depression. Nucleus accumbens (NAc) inflammation is implicated in the development and …

The medial prefrontal cortex (mPFC) receives direct and indirect projections from the ventral
hippocampus (VH) and plays an important role in the regulation of anxiety. However, the …

Background context The medial prefrontal cortex (mPFC) has been implicated in modulating
anxiety and depression. Manipulation of Drd1 neurons in the mPFC resulted in variable …

Aim of the study: Dopaminergic system in the amygdala and Prefrontal Cortex (PFC)
influences fear and anxiety through Dopaminergic Receptors (DR), especially DR-D1 and …

Dopamine in prefrontal cortices is implicated in cognitive and emotional functions, and the
dysfunction of prefrontal dopamine has been associated with cognitive and emotional …

Acute stress relates to high prevalence of anxiety, depression or even sudden death.
Although dopaminergic system in amygdala-medial prefrontal cortex (mPFC) circuit is hyper …

Background Major depressive disorder affects more than 15% of the population across their
lifespan. In this study, we used the well-characterized unpredictable chronic mild stress …

We previously demonstrated that the dopamine D3 receptor (D3R) inhibitor, NGB2904,
increases susceptibility to depressive-like symptoms, elevates pro-inflammatory cytokine …