[HTML][HTML] Immunotherapy targeting the obese white adipose tissue microenvironment: Focus on non-communicable diseases

L Priscilla, C Yoo, S Jang, S Park, G Lim, T Kim… - Bioactive Materials, 2024 - Elsevier
Obesity triggers inflammatory responses in the microenvironment of white adipose tissue,
resulting in chronic systemic inflammation and the subsequent development of non …

Immune cells in adipose tissue microenvironment under physiological and obese conditions

Y Jiang, F Gong - Endocrine, 2024 - Springer
Purpose This review will focus on the immune cells in adipose tissue microenvironment and
their regulatory roles in metabolic homeostasis of adipose tissue and even the whole body …

Therapeutic targeting of white adipose tissue metabolic dysfunction in obesity: mechanisms and opportunities

ZH Yang, FZ Chen, YX Zhang, MY Ou, PC Tan… - MedComm, 2024 - Wiley Online Library
White adipose tissue is not only a highly heterogeneous organ containing various cells,
such as adipocytes, adipose stem and progenitor cells, and immune cells, but also an …

Adipose tissue immunomodulation: a novel therapeutic approach in cardiovascular and metabolic diseases

I AlZaim, SH Hammoud, H Al-Koussa… - Frontiers in …, 2020 - frontiersin.org
Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it
secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As …

Chronic adipose tissue inflammation: all immune cells on the stage

G Cildir, SC Akıncılar, V Tergaonkar - Trends in molecular medicine, 2013 - cell.com
Inflammation is indispensable for host homeostasis against invading pathogens and efficient
wound healing upon tissue malfunction and has to be tightly controlled by various …

Metaflammation in obesity and its therapeutic targeting

MW Schleh, HL Caslin, JN Garcia… - Science translational …, 2023 - science.org
Obesity-associated inflammation is a systemic process that affects all metabolic organs.
Prominent among these is adipose tissue, where cells of the innate and adaptive immune …

Immune regulation of metabolic homeostasis in health and disease

JR Brestoff, D Artis - Cell, 2015 - cell.com
Obesity is an increasingly prevalent disease worldwide. While genetic and environmental
factors are known to regulate the development of obesity and associated metabolic …

Adipose tissue macrophage in immune regulation of metabolism

Y Qiu, B Shan, L Yang, Y Liu - Science China Life Sciences, 2016 - Springer
The prevalence of obesity and type 2 diabetes is escalating to an epidemic proportion
worldwide. Obesity is known to be associated with a state of chronic, low-grade …

Immune regulation in obesity-associated adipose inflammation

JM Han, MK Levings - The Journal of Immunology, 2013 - journals.aai.org
Adipose tissue inflammation is often a consequence of obesity and is characterized by
infiltration and activation of immune cells that overproduce cytokines and chemokines. This …

Regulation of immunometabolism in adipose tissue

M Kumari, J Heeren, L Scheja - Seminars in Immunopathology, 2018 - Springer
Adipose tissue has emerged as a major player in driving obesity-related inflammatory
response. In obesity, chronic infiltration of macrophages in adipose tissue mediates local …