[HTML][HTML] METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma
ZW Zhang, X Teng, F Zhao, C Ma, J Zhang, LF Xiao… - Cell Reports, 2022 - cell.com
Summary SHH subgroup medulloblastoma (SHH-MB) is one of the most common malignant
pediatric tumors that arises in the cerebellum. Previously, we showed that RNA m 6 A …
pediatric tumors that arises in the cerebellum. Previously, we showed that RNA m 6 A …
Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma …
Abstract Background The Sonic hedgehog (Shh) signaling pathway is critical for cell growth
and differentiation. Impairment of this pathway can result in both birth defects and cancer …
and differentiation. Impairment of this pathway can result in both birth defects and cancer …
m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells
RNA modifications play critical roles in important biological processes. However, the
functions of N 6-methyladenosine (m 6 A) mRNA modification in cancer biology and cancer …
functions of N 6-methyladenosine (m 6 A) mRNA modification in cancer biology and cancer …
OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels
Recent studies showed frequent mutations in histone H3 lysine 27 (H3K27) demethylases in
medulloblastomas of Group 3 and Group 4, suggesting a role for H3K27 methylation in …
medulloblastomas of Group 3 and Group 4, suggesting a role for H3K27 methylation in …
Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas
JI Pritchard, JM Olson - Cancer genetics and cytogenetics, 2008 - Elsevier
The Sonic hedgehog (Shh) pathway is aberrantly activated in a subset of the most common
malignant pediatric brain tumor, medulloblastoma (MB). Shh pathway activity is measured …
malignant pediatric brain tumor, medulloblastoma (MB). Shh pathway activity is measured …
MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function
Hedgehog (Hh) pathway plays a pivotal role in diverse aspects of development and
postnatal physiology. Perturbation of Hh signaling and activation of GLI1 (glioma-associated …
postnatal physiology. Perturbation of Hh signaling and activation of GLI1 (glioma-associated …
Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation
Induction of differentiation is a therapeutic strategy in high-risk neuroblastoma, a childhood
cancer of the sympathetic nervous system. Neuroblastoma differentiation requires …
cancer of the sympathetic nervous system. Neuroblastoma differentiation requires …
Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals
L Fu, H Wu, SY Cheng, D Gao, L Zhang, Y Zhao - Elife, 2016 - elifesciences.org
Hedgehog signaling plays very important roles in development and cancers. Vertebrates
have three transcriptional factors, Gli1, Gli2 and Gli3. Among them, Gli3 is a very special …
have three transcriptional factors, Gli1, Gli2 and Gli3. Among them, Gli3 is a very special …
Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma
Recent sequencing efforts have described the mutational landscape of the pediatric brain
tumor medulloblastoma. Although MLL2 is among the most frequent somatic single …
tumor medulloblastoma. Although MLL2 is among the most frequent somatic single …
Histone demethylase UTX/KDM6A enhances tumor immune cell recruitment, promotes differentiation and suppresses medulloblastoma
The deregulation of epigenetic pathways has been implicated as a critical step in
tumorigenesis including in childhood brain tumor medulloblastoma. The H3K27me3 …
tumorigenesis including in childhood brain tumor medulloblastoma. The H3K27me3 …