Abstract What is Known and Objectives Tacrolimus (TAC), a first‐line immunosuppressant in
solid‐organ transplant, has a narrow therapeutic window and large inter‐individual …

Aims The population pharmacokinetic (PPK) model-based machine learning (ML) approach
offers a novel perspective on individual concentration prediction. This study aimed to …

Abstract Background and Objective Tacrolimus is a narrow therapeutic index drug with high
pharmacokinetic variability, and several tacrolimus population pharmacokinetic (PopPK) …

Aims The aim was to develop a theory‐based population pharmacokinetic model of
tacrolimus in adult kidney transplant recipients and to externally evaluate this model and two …

Tacrolimus has a narrow therapeutic window and considerable variability in clinical use. Our
goal was to compare the performance of multiple linear regression (MLR) and eight machine …

For three decades, tacrolimus (Tac) dose adjustment in clinical practice has been calculated
empirically according to the manufacturer's labeling based on a patient's body weight. Here …

The aim of this work is to estimate the area‐under the blood concentration curve of
tacrolimus (TAC) following bid or qd dosing in organ transplant patients, using Xgboost …

Tacrolimus is a major immunosuppressor against post-transplant rejection in kidney
transplant recipients. However, the narrow therapeutic index of tacrolimus and considerable …

Aim Several tacrolimus population pharmacokinetic models in adult renal transplant
recipients have been established to facilitate dose individualization. However, their …

Aim: The aim of this study was to evaluate tacrolimus population pharmacokinetics and
investigate factors that explain tacrolimus variability in adult heart transplant patients …