Biogenesis and structure of a type VI secretion membrane core complex

E Durand, VS Nguyen, A Zoued, L Logger… - Nature, 2015 - nature.com
Bacteria share their ecological niches with other microbes. The bacterial type VI secretion
system is one of the key players in microbial competition, as well as being an important …

Biogenesis and structure of a type VI secretion baseplate

Y Cherrak, C Rapisarda, R Pellarin, G Bouvier… - Nature …, 2018 - nature.com
To support their growth in a competitive environment and cause pathogenesis, bacteria
have evolved a broad repertoire of macromolecular machineries to deliver specific effectors …

PAAR-repeat proteins sharpen and diversify the type VI secretion system spike

MM Shneider, SA Buth, BT Ho, M Basler, JJ Mekalanos… - Nature, 2013 - nature.com
The bacterial type VI secretion system (T6SS) is a large multicomponent, dynamic
macromolecular machine that has an important role in the ecology of many Gram-negative …

[HTML][HTML] Architecture and assembly of the Type VI secretion system

A Zoued, YR Brunet, E Durand, MS Aschtgen… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The Type VI secretion system (T6SS) delivers protein effectors to diverse cell types including
prokaryotic and eukaryotic cells, therefore it participates in inter-bacterial competition and …

Assembly and subcellular localization of bacterial type VI secretion systems

J Wang, M Brodmann, M Basler - Annual review of microbiology, 2019 - annualreviews.org
Bacteria need to deliver large molecules out of the cytosol to the extracellular space or even
across membranes of neighboring cells to influence their environment, prevent predation …

[PDF][PDF] A view to a kill: the bacterial type VI secretion system

BT Ho, TG Dong, JJ Mekalanos - Cell host & microbe, 2014 - cell.com
The bacterial type VI secretion system (T6SS) is an organelle that is structurally and
mechanistically analogous to an intracellular membrane-attached contractile phage tail …

Structural biology of type VI secretion systems

E Cascales, C Cambillau - Philosophical Transactions of …, 2012 - royalsocietypublishing.org
Type VI secretion systems (T6SSs) are transenvelope complexes specialized in the
transport of proteins or domains directly into target cells. These systems are versatile as they …

Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex

VS Nguyen, L Logger, S Spinelli, P Legrand… - Nature …, 2017 - nature.com
The type VI secretion system (T6SS) is a multiprotein machine widespread in Gram-negative
bacteria that delivers toxins into both eukaryotic and prokaryotic cells. The mechanism of …

Towards a Structural Comprehension of Bacterial Type VI Secretion Systems: Characterization of the TssJ-TssM Complex of an Escherichia coli Pathovar

C Felisberto-Rodrigues, E Durand, MS Aschtgen… - PLoS …, 2011 - journals.plos.org
Type VI secretion systems (T6SS) are trans-envelope machines dedicated to the secretion of
virulence factors into eukaryotic or prokaryotic cells, therefore required for pathogenesis …

Cryo-EM structure of the extended type VI secretion system sheath–tube complex

J Wang, M Brackmann, D Castano-Diez… - Nature …, 2017 - nature.com
The bacterial type VI secretion system (T6SS) uses contraction of a long sheath to quickly
thrust a tube with associated effectors across membranes of eukaryotic and bacterial cells …