Haplotype block partitioning and tag SNP selection using genotype data and their applications to association studies
Recent studies have revealed that linkage disequilibrium (LD) patterns vary across the
human genome with some regions of high LD interspersed by regions of low LD. A small …
human genome with some regions of high LD interspersed by regions of low LD. A small …
HapBlock: haplotype block partitioning and tag SNP selection software using a set of dynamic programming algorithms
Recent studies have revealed that linkage disequilibrium (LD) patterns vary across the
human genome with some regions of high LD interspersed with regions of low LD. Such LD …
human genome with some regions of high LD interspersed with regions of low LD. Such LD …
[HTML][HTML] Haplotype block structure and its applications to association studies: power and study designs
Recent studies have shown that the human genome has a haplotype block structure, such
that it can be divided into discrete blocks of limited haplotype diversity. In each block, a small …
that it can be divided into discrete blocks of limited haplotype diversity. In each block, a small …
Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome
TG Schulze, K Zhang, YS Chen, N Akula… - Human Molecular …, 2004 - academic.oup.com
Recent studies suggest that the genome is organized into blocks of haplotypes, and efforts
to create a genome-wide haplotype map of single-nucleotide polymorphisms (SNPs) are …
to create a genome-wide haplotype map of single-nucleotide polymorphisms (SNPs) are …
[HTML][HTML] Partition-ligation–expectation-maximization algorithm for haplotype inference with single-nucleotide polymorphisms
The mapping of SNPs in human genomes has generated a lot of interest from both the
biomedical research community and industry. In conjunction with SNP mapping, researchers …
biomedical research community and industry. In conjunction with SNP mapping, researchers …
Optimal haplotype block-free selection of tagging SNPs for genome-wide association studies
BV Halldorsson, V Bafna, R Lippert… - Genome …, 2004 - genome.cshlp.org
It is widely hoped that the study of sequence variation in the human genome will provide a
means of elucidating the genetic component of complex diseases and variable drug …
means of elucidating the genetic component of complex diseases and variable drug …
[HTML][HTML] The effect of single-nucleotide polymorphism marker selection on patterns of haplotype blocks and haplotype frequency estimates
M Nothnagel, K Rohde - The American Journal of Human Genetics, 2005 - cell.com
The definition of haplotype blocks of single-nucleotide polymorphisms (SNPs) has been
proposed so that the haplotypes can be used as markers in association studies and to …
proposed so that the haplotypes can be used as markers in association studies and to …
[HTML][HTML] Generating samples for association studies based on HapMap data
J Li, Y Chen - BMC bioinformatics, 2008 - Springer
Background With the completion of the HapMap project, a variety of computational
algorithms and tools have been proposed for haplotype inference, tag SNP selection and …
algorithms and tools have been proposed for haplotype inference, tag SNP selection and …
Haplotype tagging single nucleotide polymorphisms and association studies
Objectives: Discrete blocks of low haplotype diversity exist within the human genome. The
non-redundant subset of 'haplotype tagging'single nucleotide polymorphisms (htSNPs) in …
non-redundant subset of 'haplotype tagging'single nucleotide polymorphisms (htSNPs) in …
Haplotype block structures show significant variation among populations
N Liu, SL Sawyer, N Mukherjee… - … Official Publication of …, 2004 - Wiley Online Library
Recent studies suggest that haplotypes tend to have block‐like structures throughout the
human genome. Several methods were proposed for haplotype block partitioning and for …
human genome. Several methods were proposed for haplotype block partitioning and for …