A Novel Role of Connective Tissue Growth Factor in the Regulation of the Epithelial Phenotype

RP Gogoi, S Galoforo, A Fox, C Morris, H Ramos… - Cancers, 2023 - mdpi.com
Simple Summary Cancer progression and metastasis is associated with the transformation
of epithelial cells into mesenchymal cells, a process known as epithelial–mesenchymal …

Connective tissue growth factor: context‐dependent functions and mechanisms of regulation

I Cicha, M Goppelt‐Struebe - Biofactors, 2009 - Wiley Online Library
Connective tissue growth factor (CTGF, CCN2) is a secreted matricellular protein, the
functions of which depend on the interactions with other molecules in the microcellular …

Connective tissue growth factor is a positive regulator of epithelial–mesenchymal transition and promotes the adhesion with gastric cancer cells in human peritoneal …

CG Jiang, L Lv, FR Liu, ZN Wang, D Na, F Li, JB Li… - Cytokine, 2013 - Elsevier
Connective tissue growth factor (CTGF) is involved in human cancer development and
progression. Epithelial to mesenchymal transition (EMT) plays an important role in many …

Novel intracellular effects of human connective tissue growth factor expressed in Cos‐7 cells

S Kubota, T Hattori, T Shimo, T Nakanishi… - FEBS …, 2000 - Wiley Online Library
To clarify the multiple functionality of connective tissue growth factor (CTGF), we examined
the effects of nascent CTGF within the cell by transient expression. In Cos‐7 cells …

Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton

C Ott, D Iwanciw, A Graness, K Giehl… - Journal of Biological …, 2003 - ASBMB
Modulation of the cytoskeletal architecture was shown to regulate the expression of CTGF
(connective tissue growth factor, CCN2). The microtubule disrupting agents nocodazole and …

[HTML][HTML] Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer

K Moran-Jones, BS Gloss, R Murali, DK Chang… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Ovarian cancer is the most common cause of death among women with gynecologic cancer.
We examined molecular profiles of fibroblasts from normal ovary and high-grade serous …

Connective tissue growth factor: a mediator of TGF-β action on fibroblasts

GR Grotendorst - Cytokine & growth factor reviews, 1997 - Elsevier
Connective tissue growth factor (CTGF) is a cysteine-rich mitogenic peptide that binds
heparin and is secreted by fibroblasts after activation with transforming growth factor beta …

Epithelial–mesenchymal transition is regulated at post‐transcriptional levels by transforming growth factor‐β signaling during tumor progression

M Saitoh - Cancer science, 2015 - Wiley Online Library
Transforming growth factor (TGF)‐β acts as a tumor suppressor during cancer initiation, but
as a tumor promoter during tumor progression. It has become increasingly clear that TGF‐β …

Connective tissue growth factor (CTGF) and cancer progression

CY Chu, CC Chang, E Prakash, ML Kuo - Journal of biomedical science, 2008 - Springer
Connective tissue growth factor (CTGF) is a member of the CCN family of secreted, matrix-
associated proteins encoded by immediate early genes that play various roles in …

Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation

GR Grotendorst, MR Duncan - The FASEB Journal, 2005 - Wiley Online Library
All members of the Ctgf, Cyr61, and Nov (CCN) family share a high degree of sequence
homology and conservation of structural motifs and domains. Here, we present data about a …