A Novel Role of Connective Tissue Growth Factor in the Regulation of the Epithelial Phenotype
RP Gogoi, S Galoforo, A Fox, C Morris, H Ramos… - Cancers, 2023 - mdpi.com
Simple Summary Cancer progression and metastasis is associated with the transformation
of epithelial cells into mesenchymal cells, a process known as epithelial–mesenchymal …
of epithelial cells into mesenchymal cells, a process known as epithelial–mesenchymal …
Connective tissue growth factor: context‐dependent functions and mechanisms of regulation
I Cicha, M Goppelt‐Struebe - Biofactors, 2009 - Wiley Online Library
Connective tissue growth factor (CTGF, CCN2) is a secreted matricellular protein, the
functions of which depend on the interactions with other molecules in the microcellular …
functions of which depend on the interactions with other molecules in the microcellular …
Connective tissue growth factor is a positive regulator of epithelial–mesenchymal transition and promotes the adhesion with gastric cancer cells in human peritoneal …
CG Jiang, L Lv, FR Liu, ZN Wang, D Na, F Li, JB Li… - Cytokine, 2013 - Elsevier
Connective tissue growth factor (CTGF) is involved in human cancer development and
progression. Epithelial to mesenchymal transition (EMT) plays an important role in many …
progression. Epithelial to mesenchymal transition (EMT) plays an important role in many …
Novel intracellular effects of human connective tissue growth factor expressed in Cos‐7 cells
S Kubota, T Hattori, T Shimo, T Nakanishi… - FEBS …, 2000 - Wiley Online Library
To clarify the multiple functionality of connective tissue growth factor (CTGF), we examined
the effects of nascent CTGF within the cell by transient expression. In Cos‐7 cells …
the effects of nascent CTGF within the cell by transient expression. In Cos‐7 cells …
Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton
C Ott, D Iwanciw, A Graness, K Giehl… - Journal of Biological …, 2003 - ASBMB
Modulation of the cytoskeletal architecture was shown to regulate the expression of CTGF
(connective tissue growth factor, CCN2). The microtubule disrupting agents nocodazole and …
(connective tissue growth factor, CCN2). The microtubule disrupting agents nocodazole and …
[HTML][HTML] Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer
Ovarian cancer is the most common cause of death among women with gynecologic cancer.
We examined molecular profiles of fibroblasts from normal ovary and high-grade serous …
We examined molecular profiles of fibroblasts from normal ovary and high-grade serous …
Connective tissue growth factor: a mediator of TGF-β action on fibroblasts
GR Grotendorst - Cytokine & growth factor reviews, 1997 - Elsevier
Connective tissue growth factor (CTGF) is a cysteine-rich mitogenic peptide that binds
heparin and is secreted by fibroblasts after activation with transforming growth factor beta …
heparin and is secreted by fibroblasts after activation with transforming growth factor beta …
Epithelial–mesenchymal transition is regulated at post‐transcriptional levels by transforming growth factor‐β signaling during tumor progression
M Saitoh - Cancer science, 2015 - Wiley Online Library
Transforming growth factor (TGF)‐β acts as a tumor suppressor during cancer initiation, but
as a tumor promoter during tumor progression. It has become increasingly clear that TGF‐β …
as a tumor promoter during tumor progression. It has become increasingly clear that TGF‐β …
Connective tissue growth factor (CTGF) and cancer progression
CY Chu, CC Chang, E Prakash, ML Kuo - Journal of biomedical science, 2008 - Springer
Connective tissue growth factor (CTGF) is a member of the CCN family of secreted, matrix-
associated proteins encoded by immediate early genes that play various roles in …
associated proteins encoded by immediate early genes that play various roles in …
Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation
GR Grotendorst, MR Duncan - The FASEB Journal, 2005 - Wiley Online Library
All members of the Ctgf, Cyr61, and Nov (CCN) family share a high degree of sequence
homology and conservation of structural motifs and domains. Here, we present data about a …
homology and conservation of structural motifs and domains. Here, we present data about a …