GABA A receptors are ligand-gated ion channels composed of five subunits that can be
opened by GABA and be modulated by multiple pharmacologically and clinically important …

Gamma-aminobutyric acid (GABA) is the most important inhibitory transmitter in the central
nervous system. Most of the actions of GABA are mediated by GABAA receptors. These are …

Gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the mammalian
central nervous system, plays a key role in the regulation of neuronal transmission …

A high degree of structural heterogeneity of the GABA A receptors (GABA A Rs) has been
revealed and is reflected in multiple receptor subtypes. The subunit composition of GABA …

GABA A receptors are Cl− channels that can be opened by GABA and are the major
inhibitory neurotransmitter receptors in the CNS. A variety of pharmacologically important …

GABA A receptors are pentameric ligand-gated ion channels that mediate most fast
neuronal inhibition in the brain. In addition to their important physiological roles, they are …

The presence of allosteric binding sites on recombinant GABAA receptors formed after
transfection of human embryonic kidney (HEK) 293 cells with α1-, β3-, γ2-subunits, or with …

Abstract GABA A receptors (GABA A Rs) are a class of ligand-gated ion channels with high
physiological and therapeutic significance. In the brain, these pentameric receptors occur …

Abstract GABA A receptors (GABA A Rs) mediate rapid inhibitory transmission in the brain.
GABA A Rs are ligand-gated chloride ion channel proteins and exist in about a dozen or …

GABA A receptors, mediators of fast inhibitory neurotransmission, are heteropentameric
assemblies from a large array of subunits. Differences in the sensitivity of receptor subtypes …