Pathogenesis of osteoarthritis: risk factors, regulatory pathways in chondrocytes, and experimental models

Y He, Z Li, PG Alexander, BD Ocasio-Nieves, L Yocum… - Biology, 2020 - mdpi.com
As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

[HTML][HTML] Current concepts in the pathogenesis of osteoarthritis

S Krasnokutsky, M Attur, G Palmer, J Samuels… - Osteoarthritis and …, 2008 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease that progressively causes loss of joint
function and is the leading source of physical disability and impaired quality of life in …

Emerging targets in osteoarthritis therapy

MB Goldring, F Berenbaum - Current opinion in pharmacology, 2015 - Elsevier
Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets

HI Roach, T Aigner, S Soder, J Haag… - Current Drug …, 2007 - ingentaconnect.com
Osteoarthritis, a degenerative joint disease, is the most disabling condition of the Western
world. It affects first and foremost the articular cartilages and leads to a molecular and …

[HTML][HTML] An update on the pathophysiology of osteoarthritis

A Mobasheri, M Batt - Annals of physical and rehabilitation medicine, 2016 - Elsevier
Introduction Osteoarthritis (OA) is one of the most common forms of arthritis. There is
accumulating evidence to suggest that OA is an inflammatory disease of the entire synovial …

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

DI Chen, J Shen, W Zhao, T Wang, L Han, JL Hamilton… - Bone research, 2017 - nature.com
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

Therapeutics in osteoarthritis based on an understanding of its molecular pathogenesis

JR Kim, JJ Yoo, HA Kim - International journal of molecular sciences, 2018 - mdpi.com
Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized
by the progressive destruction of articular cartilage, synovial inflammation, changes in …

Osteoarthritis: New insight on its pathophysiology

S Coaccioli, P Sarzi-Puttini, P Zis, G Rinonapoli… - Journal of Clinical …, 2022 - mdpi.com
Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …

Pathophysiological perspective of osteoarthritis

MHM Yunus, A Nordin, H Kamal - Medicina, 2020 - mdpi.com
Osteoarthritis (OA) is the most well-known degenerative disease among the geriatric and is
a main cause of significant disability in daily living. It has a multifactorial etiology and is …