Addiction, also known as severe substance use disorder, is characterised by compulsive
drug-seeking and intake in the face of mounting adverse and negative consequences …

Only some individuals using drugs recreationally eventually become addicted, and persist in
drug seeking and taking despite adverse consequences. The neurobehavioral determinants …

Background Only some individuals who use drugs recreationally eventually develop a
substance use disorder, characterized in part by the rigid engagement in drug foraging …

Drug addiction is widely recognized to afflict some but not all individuals by virtue of
underlying risk markers and traits involving multifaceted interactions between polygenic and …

Substance abuse disorder is a chronically relapsing disease that is characterized in part by
compulsion to seek and take drug in the presence of adverse consequences and in …

Many people use opioid drugs medically and some abuse them recreationally, but only a
few of these go on to develop diagnosable substance use disorders [1]. Thus, a major goal …

Current neurobiological models define addiction as a transition in behavioral control from
impulsive to compulsive mechanisms, underpinned by neuroplasticity in frontal-striatal …

BACKGROUND The differential utility of neurocognitive impulsivity and externalizing/
internalizing traits as putative addiction endophenotypes among individuals dependent on …

Drug compulsion manifests in some but not all individuals and implicates multifaceted
processes including failures in top‐down cognitive control as drivers for the hazardous …

Impulsivity and compulsivity are key neurobiological mechanisms of addiction that are at
complex interplay throughout the development and maintenance of substance use disorders …