Brain substrates of behavioural endophenotypes predictive of compulsive drug-seeking
J Jones - 2022 - repository.cam.ac.uk
Addiction, also known as severe substance use disorder, is characterised by compulsive
drug-seeking and intake in the face of mounting adverse and negative consequences …
drug-seeking and intake in the face of mounting adverse and negative consequences …
Neurobehavioral precursors of compulsive cocaine-seeking in dual fronto-striatal circuits
Only some individuals using drugs recreationally eventually become addicted, and persist in
drug seeking and taking despite adverse consequences. The neurobehavioral determinants …
drug seeking and taking despite adverse consequences. The neurobehavioral determinants …
[HTML][HTML] Neurobehavioral precursors of compulsive cocaine seeking in dual Frontostriatal circuits
JA Jones, A Belin-Rauscent, B Jupp… - … Psychiatry Global Open …, 2024 - Elsevier
Background Only some individuals who use drugs recreationally eventually develop a
substance use disorder, characterized in part by the rigid engagement in drug foraging …
substance use disorder, characterized in part by the rigid engagement in drug foraging …
In search of predictive endophenotypes in addiction: insights from preclinical research
Drug addiction is widely recognized to afflict some but not all individuals by virtue of
underlying risk markers and traits involving multifaceted interactions between polygenic and …
underlying risk markers and traits involving multifaceted interactions between polygenic and …
Mechanisms regulating compulsive drug behaviors
Substance abuse disorder is a chronically relapsing disease that is characterized in part by
compulsion to seek and take drug in the presence of adverse consequences and in …
compulsion to seek and take drug in the presence of adverse consequences and in …
Do striatal push/pull circuits hold the key to compulsive, relapsing heroin addiction? A Research Highlight on: Chemogenetic modulation of accumbens direct or …
Many people use opioid drugs medically and some abuse them recreationally, but only a
few of these go on to develop diagnosable substance use disorders [1]. Thus, a major goal …
few of these go on to develop diagnosable substance use disorders [1]. Thus, a major goal …
From impulses to compulsions
K Raj, A Verdejo-Garcia - Cognition and addiction, 2020 - Elsevier
Current neurobiological models define addiction as a transition in behavioral control from
impulsive to compulsive mechanisms, underpinned by neuroplasticity in frontal-striatal …
impulsive to compulsive mechanisms, underpinned by neuroplasticity in frontal-striatal …
Neurocognitive and psychiatric markers for addiction: Common vs. specific (endo) phenotypes for opiate and stimulant dependence
BACKGROUND The differential utility of neurocognitive impulsivity and externalizing/
internalizing traits as putative addiction endophenotypes among individuals dependent on …
internalizing traits as putative addiction endophenotypes among individuals dependent on …
Neurochemical substrates linked to impulsive and compulsive phenotypes in addiction: A preclinical perspective
JA Jones, K Zuhlsdorff, JW Dalley - Journal of Neurochemistry, 2021 - Wiley Online Library
Drug compulsion manifests in some but not all individuals and implicates multifaceted
processes including failures in top‐down cognitive control as drivers for the hazardous …
processes including failures in top‐down cognitive control as drivers for the hazardous …
[引用][C] Compulsivity and Impulsivity Dimensions as Familial Neurocognitive Markers of Heroin Addiction
J Vassileva, E Psederska - Biological Psychiatry …, 2024 - biologicalpsychiatrycnni.org
Impulsivity and compulsivity are key neurobiological mechanisms of addiction that are at
complex interplay throughout the development and maintenance of substance use disorders …
complex interplay throughout the development and maintenance of substance use disorders …