Transcription of eukaryotic genes by RNA polymerase II (Pol II) yields RNA precursors
containing introns that must be spliced out and the flanking exons ligated together. Splicing …

The discovery that many intron-containing genes can be cotranscriptionally spliced has led
to an increased understanding of how splicing and transcription are intricately intertwined …

Nascent transcripts are the true substrates for many splicing events in mammalian cells. In
this review we discuss transcription, splicing, and alternative splicing in the context of co …

Splicing of RNA polymerase II transcripts is a crucial step in gene expression and a key
generator of mRNA diversity. Splicing and transcription have generally been studied in …

Several macromolecular machines collaborate to produce eukaryotic messenger RNA. RNA
polymerase II (Pol II) translocates along genes that are up to millions of base pairs in length …

Alternative splicing regulation not only depends on the interaction of splicing factors with
splicing enhancers and silencers in the pre-mRNA, but also on the coupling between …

RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

Transcription and pre-mRNA splicing are extremely complex multimolecular processes that
involve protein–DNA, protein–RNA, and protein–protein interactions. Splicing occurs in the …

Increasing evidence indicates that the transcriptional machinery can influence the efficiency
of splicing as well as splice-site selection. Surprisingly, it has now been demonstrated that …

A characteristic feature of eukaryotic cells is that the primary transcription products of their
structural genes (pre-mRNAs) undergo a variety of post transcriptional modifications to …