Innate immunity is one of the main protection mechanisms against viral infections, but how
this system works at the maternal-fetal interface, especially during HIV infection, is still poorly …

The transfer of maternal immune factors to the newborn is critical for protection from
infectious disease in early life. Maternally acquired passive immunity provides protection …

The placenta, the first and largest organ to develop after conception, not only nurtures and
promotes the development of the conceptus, but, it also functions as a barrier against …

In 2019,> 90% of new HIV infections in infants globally occurred vertically. Studies suggest
intrauterine transmission most often occurs in the third trimester; however, there are no …

Early life represents a period of profound immunological development and heightened
susceptibility to infectious disease. The developmental trajectory over this period is …

Maternal factors and exposure to pathogens have an impact on infant health. For instance,
HIV exposed but uninfected infants have higher morbidity and mortality than HIV unexposed …

Programs for the prevention of mother-to-child transmission of HIV have reduced the
transmission rate of perinatal HIV infection and have thereby increased the number of HIV …

Maternal HIV infection is associated with an increased risk of preterm birth (PTB). However,
the mechanisms underlying this increased risk in women with HIV remain poorly …

The maternal-fetal interface during pregnancy is an underexplored environment rich in
immunological factors that must propel developmental processes while simultaneously …

HIV infection in pregnant women is associated with altered immune responses in HIV-
infected women and their offspring with clinical consequences for pregnancy outcome and …