We have studied a role of immunological balance in connection to allergen challenge in
asthma patients and in connection to apheresis treatment in inflammatory bowel disease …

It is now over 10 years ago that two populations of T helper cells TH1 and TH2 were
recognized in mice [1, 2] and led to the recognition of a similar, but not identical …

The pathophysiology of asthma is complex and engages cascades of events in the cytokine
network. We, therefore, investigated the impact of bronchial allergen challenge in humans …

Background: Recently, diminished interferon-γ (IFN-γ) and increased interleukin (IL)-4
production in peripheral blood mononuclear cells (PBMCs) from atopic patients have been …

It has been postulated that T lymphocytes orchestrate the chronic inflammation in bronchial
asthma. In animal models, infiltration of CD8+ T lymphocytes into the bronchial mucosa …

RESULTS Consistent with previous studies, the percentage of CD4+ CD25+ regulatory T
cells in CD4+ T cells decreased in asthmatic patients. Most importantly, the expression of …

ABSTRACT Functional imbalance in Th1/Th2 cell response toward allergens is a
recognized hallmark of allergic patients and a major role of dendritic cells (DCs) in …

In order to determine whether the dissection of helper/inducer (CD4+) and
suppressor/cytotoxic (CD8+) lymphocyte subsets with Leu 8 reagent would reveal any …

Allergic diseases are characterized by cellular infiltration and production of mediators at the
site of the affected organ and the presence of circulating specific IgE antibodies against …

Background During the pollen season, peripheral blood mononuclear cells (PBMC) from
allergic patients produce increased levels of Th2 cytokines after stimulation with allergen in …