Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …
on gene expression, we measured methylation, RNA polymerase occupancy and histone …
DNA methylation: old dog, new tricks?
CG Spruijt, M Vermeulen - Nature structural & molecular biology, 2014 - nature.com
DNA methylation is an epigenetic modification that is generally associated with repression of
transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent …
transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent …
DNA methylation profiling of human chromosomes 6, 20 and 22
F Eckhardt, J Lewin, R Cortese, VK Rakyan, J Attwood… - Nature …, 2006 - nature.com
DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
M Weber, JJ Davies, D Wittig, EJ Oakeley, M Haase… - Nature …, 2005 - nature.com
Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …
human cancer. To determine how this epigenetic modification is distributed in the genomes …
Methylation meets genomics
AP Feinberg - Nature genetics, 2001 - nature.com
I respectfully propose this neologism because it serves to formally unite the study of DNA
methylation with the power of modern genomics. At this writing, the word does not appear in …
methylation with the power of modern genomics. At this writing, the word does not appear in …
Population-specificity of human DNA methylation
Background Ethnic differences in human DNA methylation have been shown for a number of
CpG sites, but the genome-wide patterns and extent of these differences are largely …
CpG sites, but the genome-wide patterns and extent of these differences are largely …
Extensive sequence-influenced DNA methylation polymorphism in the human genome
A Hellman, A Chess - Epigenetics & chromatin, 2010 - Springer
Background Epigenetic polymorphisms are a potential source of human diversity, but their
frequency and relationship to genetic polymorphisms are unclear. DNA methylation, an …
frequency and relationship to genetic polymorphisms are unclear. DNA methylation, an …
Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns
JR Edwards, AH O'Donnell, RA Rollins… - Genome …, 2010 - genome.cshlp.org
Abnormalities of genomic methylation patterns are lethal or cause disease, but the cues that
normally designate CpG dinucleotides for methylation are poorly understood. We have …
normally designate CpG dinucleotides for methylation are poorly understood. We have …
Charting a dynamic DNA methylation landscape of the human genome
DNA methylation is a defining feature of mammalian cellular identity and is essential for
normal development,. Most cell types, except germ cells and pre-implantation embryos …
normal development,. Most cell types, except germ cells and pre-implantation embryos …
DNA methylation: roles in mammalian development
ZD Smith, A Meissner - Nature Reviews Genetics, 2013 - nature.com
DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …
mammalian development. Although the methylation status of most CpG dinucleotides in the …