Redox regulation and metabolic dependency of Zika virus replication: Inhibition by Nrf2-antioxidant response and NAD (H) antimetabolites

BR Sahoo, AA Crook, A Pattnaik… - Journal of …, 2023 - Am Soc Microbiol
Viral infections alter host cell metabolism and homeostasis; however, the mechanisms that
regulate these processes have only begun to be elucidated. We report here that Zika virus …

[HTML][HTML] Zika virus induces oxidative stress and decreases antioxidant enzyme activities in vitro and in vivo

LT Almeida, AC Ferraz, CC da Silva Caetano… - Virus research, 2020 - Elsevier
The first outbreak of Zika virus (ZIKV) infection in the Americas, especially in Brazil, was
reported in 2015. Fever, headache, rash, and conjunctivitis are the common symptoms of …

Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways

S Denolly, A Stukalov, U Barayeu, AN Rosinski… - Nature …, 2023 - nature.com
Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor a
vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm in close …

Zika virus infection reprograms global transcription of host cells to allow sustained infection

SK Tiwari, J Dang, Y Qin, G Lichinchi… - Emerging microbes & …, 2017 - Taylor & Francis
Zika virus (ZIKV) is an emerging virus causally linked to neurological disorders, including
congenital microcephaly and Guillain–Barré syndrome. There are currently no targeted …

Complementary mechanisms potentially involved in the pathology of Zika virus

CR Ojha, M Rodriguez, J Lapierre… - Frontiers in …, 2018 - frontiersin.org
Zika virus (ZIKV) has emerged as a global health threat due to its neuro-teratogenic effect
and wide range of transmission routes. Most recently, ZIKV infection has been linked with …

Piperlongumine Inhibits Zika Virus Replication In vitro and Promotes Up-Regulation of HO-1 Expression, Suggesting An Implication of Oxidative Stress

W Lu, L Shi, J Gao, H Zhu, Y Hua, J Cai, X Wu, C Wan… - Virologica Sinica, 2021 - Springer
Owing to the widespread distribution of mosquitoes capable of transmitting Zika virus, lack of
clinical vaccines and treatments, and poor immunity of populations to new infectious …

A review of the ongoing research on Zika virus treatment

S Da Silva, D Oliveira Silva Martins, ACG Jardim - Viruses, 2018 - mdpi.com
The Zika fever is an arboviral disease resulting from the infection with Zika virus (ZIKV). The
virus is transmitted to humans by the bite of Aedes mosquitos, mainly Aedes aegypti and …

Resveratrol affects Zika virus replication in vitro

A Mohd, N Zainal, KK Tan, S AbuBakar - Scientific reports, 2019 - nature.com
Zika virus (ZIKV) infection is a serious public health concern. ZIKV infection has been
associated with increased occurrences of microcephaly among newborns and incidences of …

Insights into zika virus pathogenesis and potential therapeutic strategies

N Camacho-Concha, ME Santana-Román… - Biomedicines, 2023 - mdpi.com
Zika virus (ZIKV) has emerged as a significant public health threat, reaching pandemic
levels in 2016. Human infection with ZIKV can manifest as either asymptomatic or as an …

Identification and characterization of Zika virus NS5 methyltransferase inhibitors

W Song, H Zhang, Y Zhang, Y Chen, Y Lin… - Frontiers in Cellular …, 2021 - frontiersin.org
The recurring outbreak of Zika virus (ZIKV) worldwide makes an emergent demand for novel,
safe and efficacious anti-ZIKV agents. ZIKV non-structural protein 5 (NS5) methyltransferase …