A multi-modal volumetric microscope with automated sample handling for surveying microbial life in liquid samples

T Kim, N Oborny, E Serabyn, JK Wallace… - Frontiers in Astronomy …, 2022 - frontiersin.org
In the study of microbial life, microscopy plays a unique role due to its ability to detect
ordered structure, motility, and fluorescence signals. As such it has also recently gained …

Demonstration of a dual-mode digital-holographic/light-field-fluorescence microscope for extant life searches

E Serabyn, T Kim, K Liewer… - 2020 IEEE …, 2020 - ieeexplore.ieee.org
A promising way to search for microbial life in our solar system's Ocean Worlds is to make
use of 3-d microscopes, as these can provide single-image inventories of the complete …

Development of a light-field fluorescence microscope for in situ life searches in the solar system

G Serabyn, K Liewer, C Lindensmith… - 2019 IEEE …, 2019 - ieeexplore.ieee.org
With oceans and energy sources present on several outer solar system moons, it is natural
ask whether life might also be present on such bodies. To search for microbial life, 3-d …

A submersible, off-axis holographic microscope for detection of microbial motility and morphology in aqueous and icy environments

CA Lindensmith, S Rider, M Bedrossian, JK Wallace… - PloS one, 2016 - journals.plos.org
Sea ice is an analog environment for several of astrobiology's near-term targets: Mars,
Europa, Enceladus, and perhaps other Jovian or Saturnian moons. Microorganisms, both …

Digital Holographic Microscopy for the Icefin Underwater Vehicle: Initial Progress and Future Steps

AD Mullen, BE Schmidt, D Dichek… - The Astrobiology …, 2019 - ui.adsabs.harvard.edu
Effective searches for life on icy worlds such as Europa will require: instruments capable of
detecting microbial organisms, robotic platforms for exploration, and systems designed for …

Digital holographic microscopy, a method for detection of microorganisms in plume samples from Enceladus and other icy worlds

M Bedrossian, C Lindensmith, JL Nadeau - Astrobiology, 2017 - liebertpub.com
Detection of extant microbial life on Earth and elsewhere in the Solar System requires the
ability to identify and enumerate micrometer-scale, essentially featureless cells. On Earth …

ELVIS: a correlated light-field and digital holographic microscope for field and laboratory investigations

T Kim, E Serabyn, M Schadegg, K Liewer… - Microscopy …, 2020 - academic.oup.com
This is the first of two articles on the Extant Life Volumetric Imaging System (ELVIS)
describing a combined digital holographic microscope (DHM) and a fluorescence light-field …

Design of a Low-cost, Submersible, Digital Holographic Microscope for in Situ Microbial Imaging

A Ramirez, T Burch, JK Wallace - 2022 IEEE Aerospace …, 2022 - ieeexplore.ieee.org
The methodologies for studying marine microbiology typically consist of utilizing
instrumentation within a laboratory. This typically requires extracting a sample from its place …

In-line digital holographic microscopy for terrestrial and exobiological research

SK Jericho, P Klages, J Nadeau, EM Dumas… - Planetary and Space …, 2010 - Elsevier
We describe here a simple digital in-line holographic microscope (DIHM) that was used to
investigate the microbial life forms that exist in perennial springs and glacial melt-water …

Quantifying microorganisms at low concentrations using digital holographic microscopy (DHM)

M Bedrossian, C Barr, CA Lindensmith… - JoVE (Journal of …, 2017 - jove.com
Accurately detecting and counting sparse bacterial samples has many applications in the
food, beverage, and pharmaceutical processing industries, in medical diagnostics, and for …