Drug therapy has a crucial role in the treatment of viral, bacterial, fungal and protozoan
infections, as well as the control of human cancer. The success of therapy is being …

The evolution of drug-resistant pathogens is a major challenge for 21st century medicine.
Drug use practices vigorously advocated as resistance management tools by professional …

Evolutionary biologists have largely left the search for solutions to the drug resistance crisis
to biomedical scientists, physicians, veterinarians and public health specialists. We believe …

Understanding the frequency with which new resistance alleles arise and their subsequent
patterns of spread is critical to our attempts to manage drug resistance in parasite …

It is widely assumed in genetics that most mutations disrupt metabolism to some extent, and
are consequently likely to be disadvantageous for the organisms that inherit them. This may …

Drug resistant pathogens are one of the key public health challenges of the 21st century.
There is a widespread belief that resistance is best managed by using drugs to rapidly …

Although caused by vastly different pathogens, the world's three most serious infectious
diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug …

Plasmodium falciparum and Plasmodium vivax, the two protozoan parasite species that
cause the majority of cases of human malaria, have developed resistance to nearly all …

Microbial resistance to chemotherapy has caused countless deaths where malaria is
endemic. Chemotherapy may fail either due to pre-existing resistance or evolution of drug …

Antiviral drug resistance is a matter of great clinical importance that, historically, has been
investigated mostly from a virological perspective. Although the proximate mechanisms of …