Large bone defects resulting from fractures and disease are a major clinical challenge,
being often unable to heal spontaneously by the body's repair mechanisms. Lines of …

Aging exacerbates the dysfunction of tissue regeneration at multiple levels and gradually
diminishes individual's capacity to withstand stress, damage, and disease. The excessive …

Bone repair in patients with osteoporosis remains a big challenge because their injury sites
are often accompanied by an abnormal level of inflammation and reactive oxygen species …

Reactive oxygen species (ROS) plays a critical role in tissue repair, including bone.
Therefore, detecting and regulating ROS is essential for monitoring and facilitating bone …

Large bone defect repair requires biomaterials that promote angiogenesis and
osteogenesis. In present work, a nanoclay (Laponite, XLS)-functionalized 3D bioglass (BG) …

Recent innovations in bone tissue engineering have introduced biomaterials that generate
oxygen to substitute vasculature. This strategy provides the immediate oxygen required for …

Overcoming hypoxia and providing a proper microenvironment for osteogenic differentiation
are the most critical challenges in bone tissue engineering (BTE). Hydrogels with the …

Hypoxia, the result of disrupted vasculature, can be categorized in the main limiting factors
for fracture healing. A lack of oxygen can cause cell apoptosis, tissue necrosis, and late …

Low oxygen pressure (hypoxia) plays an important role in stimulating angiogenesis; there
are, however, few studies to prepare hypoxia-mimicking tissue engineering scaffolds …

Bone defects in osteoporosis usually present excessive reactive oxygen species (ROS),
abnormal inflammation levels, irregular shapes and impaired bone regeneration ability; …