Involvement of astrocytes in Alzheimer's disease from a neuroinflammatory and oxidative stress perspective

RE González-Reyes, MO Nava-Mesa… - Frontiers in molecular …, 2017 - frontiersin.org
Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …

Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer's disease

C Li, R Zhao, K Gao, Z Wei… - Current Alzheimer …, 2011 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disease with major clinical hallmarks of
memory loss, dementia, and cognitive impairment. Neuroinflammation is involved in the …

Amyloid-β and astrocytes interplay in amyloid-β related disorders

YS Batarseh, QV Duong, YM Mousa… - International journal of …, 2016 - mdpi.com
Amyloid-β (Aβ) pathology is known to promote chronic inflammatory responses in the brain.
It was thought previously that Aβ is only associated with Alzheimer's disease and Down …

Glial cells in Alzheimer's disease: From neuropathological changes to therapeutic implications

MS Uddin, LW Lim - Ageing research reviews, 2022 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and
progressively worsens over time. Although there has been increasing research interest in …

When astrocytes become harmful: functional and inflammatory responses that contribute to Alzheimer's disease

E Avila-Muñoz, C Arias - Ageing research reviews, 2014 - Elsevier
A growing body of research suggests that astrocytes play roles as contributors to the
pathophysiology of Alzheimer's disease (AD). Several lines of evidence propose that …

Reactive astrocytes as drug target in Alzheimer's disease

BT Assefa, AK Gebre, BM Altaye - BioMed research …, 2018 - Wiley Online Library
Alzheimer's disease is a neurodegenerative disease characterized by deposition of
extracellular amyloid‐β, intracellular neurofibrillary tangles, and loss of cortical neurons …

Reactive astrocytes in Alzheimer's disease: A double-edged sword

H Chun, CJ Lee - Neuroscience research, 2018 - Elsevier
Alzheimer's disease (AD) is a chronic and fatal disease, in which neuronal damage at its late
stage cannot be easily reversed. Because AD progression is caused by multiple factors …

Does neuroinflammation turn on the flame in Alzheimer's disease? Focus on astrocytes

L Steardo Jr, MR Bronzuoli, A Iacomino… - Frontiers in …, 2015 - frontiersin.org
Data from animal models and Alzheimer's disease (AD) subjects provide clear evidence for
an activation of inflammatory pathways during the pathogenetic course of such illness …

Astrocytes and neuroinflammation in Alzheimer's disease

EC Phillips, CL Croft, K Kurbatskaya, MJ O'Neill… - 2014 - portlandpress.com
Increased production of amyloid β-peptide (Aβ) and altered processing of tau in Alzheimer's
disease (AD) are associated with synaptic dysfunction, neuronal death and cognitive and …

Glia-driven neuroinflammation and systemic inflammation in Alzheimer's disease

S Hashioka, Z Wu, A Klegeris - Current Neuropharmacology, 2021 - ingentaconnect.com
The neuroinflammatory hypothesis of Alzheimer's disease (AD) was proposed more than 30
years ago. The involvement of the two main types of glial cells microglia and astrocytes, in …