The present invention provides novel pyrimidine amines of formula I which are potent
inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of …

The present invention provides novel pyrimidine amines of formula I which are potent
inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment …

Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine
kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease …

This application is filed pursuant to 35 USC S371 as a United States National Phase
Application of International Patent Application No. PCT/EP2010/050228 filed Jan. 11, 2010 …

0001. The present invention relates to certain amino-pyri dine-containing compounds of the
Formula (I)(also referred to herein as the “compounds of the Formula (I) or “com pounds of …

Int. Cl. C07D 403/12(2006.01) The present invention provides novel imidazole analogs of
C07D 403/14(2006.01) Formula I which are potent inhibitors of spleen tyrosine C07D …

US20170152258A9 - Substituted Pyridopyrazines as Syk Inhibitors - Google Patents
US20170152258A9 - Substituted Pyridopyrazines as Syk Inhibitors - Google Patents …

BACKGROUND Protein kinases, the largest family of human enzymes, 20 encompass well
over 500 proteins. Spleen Tyrosine Kinase (Syk) is a member of the Syk family of tyrosine …

0001 Spleen Tyrosine Kinase (Syk) is a protein tyrosine kinase which has been described
as a key mediator of immu noreceptor signalling in a host of inflammatory cells includ ing …

0001. This invention relates to substituted 1, 6-naphthy ridines that inhibit SYK kinase. In
one embodiment, this invention relates to a novel class of Substituted 1, 6-naph thyridines …