Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …

Systemic autoimmune diseases arise from loss of self-tolerance and immune homeostasis
between effector and regulator functions. There are many therapeutic modalities for …

Standard treatments for autoimmune and autoinflammatory disorders rely mainly on
immunosuppression. These are predominantly symptomatic remedies that do not affect the …

Cellular therapies have potential to treat a wide range of diseases with autologous
immunotherapies showing unprecedented therapeutic promise in clinical trials. Such …

Autoimmune disease, caused by unwanted immune responses to self-antigens, affects
millions of people each year and poses a great social and economic burden to individuals …

Cellular therapies are poised to transform the field of medicine by restoring dysfunctional
tissues and treating various diseases in a dynamic manner not achievable by conventional …

Autoimmunity occurs when T cells, B cells or both are inappropriately activated, resulting in
damage to one or more organ systems. Normally, high-affinity self-reactive T and B cells are …

Cell therapies present an entirely new paradigm in drug development. Within this class,
immune cell therapies are among the most advanced, having already demonstrated …

Despite major progress in the treatment of autoimmune diseases in the past two decades,
most therapies do not cure disease and can be associated with increased risk of infection …

Autoimmune diseases are caused by immune cells attacking the host tissues they are
supposed to protect. Recent advances suggest that maintaining a balance of effector and …