Translation of cell therapies to treat autoimmune disorders
Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …
impact on patient quality of life and a significant global healthcare burden. Current …
[HTML][HTML] Recent advances in cell therapeutics for systemic autoimmune diseases
Y Park, SK Kwok - Immune Network, 2022 - ncbi.nlm.nih.gov
Systemic autoimmune diseases arise from loss of self-tolerance and immune homeostasis
between effector and regulator functions. There are many therapeutic modalities for …
between effector and regulator functions. There are many therapeutic modalities for …
The emerging jamboree of transformative therapies for autoimmune diseases
JM Carballido, C Regairaz, C Rauld, L Raad… - Frontiers in …, 2020 - frontiersin.org
Standard treatments for autoimmune and autoinflammatory disorders rely mainly on
immunosuppression. These are predominantly symptomatic remedies that do not affect the …
immunosuppression. These are predominantly symptomatic remedies that do not affect the …
Clinical development of cell therapies: setting the stage for academic success
M Abou‐El‐Enein, HD Volk… - Clinical Pharmacology & …, 2017 - Wiley Online Library
Cellular therapies have potential to treat a wide range of diseases with autologous
immunotherapies showing unprecedented therapeutic promise in clinical trials. Such …
immunotherapies showing unprecedented therapeutic promise in clinical trials. Such …
The emerging role of regulatory cell-based therapy in autoimmune disease
F Ghobadinezhad, N Ebrahimi, F Mozaffari… - Frontiers in …, 2022 - frontiersin.org
Autoimmune disease, caused by unwanted immune responses to self-antigens, affects
millions of people each year and poses a great social and economic burden to individuals …
millions of people each year and poses a great social and economic burden to individuals …
[HTML][HTML] Emerging immunomodulatory strategies for cell therapeutics
Cellular therapies are poised to transform the field of medicine by restoring dysfunctional
tissues and treating various diseases in a dynamic manner not achievable by conventional …
tissues and treating various diseases in a dynamic manner not achievable by conventional …
Restoring the balance: immunotherapeutic combinations for autoimmune disease
DE Smilek, MR Ehlers… - Disease models & …, 2014 - journals.biologists.com
Autoimmunity occurs when T cells, B cells or both are inappropriately activated, resulting in
damage to one or more organ systems. Normally, high-affinity self-reactive T and B cells are …
damage to one or more organ systems. Normally, high-affinity self-reactive T and B cells are …
The emerging landscape of immune cell therapies
Cell therapies present an entirely new paradigm in drug development. Within this class,
immune cell therapies are among the most advanced, having already demonstrated …
immune cell therapies are among the most advanced, having already demonstrated …
Sequential immunotherapy: towards cures for autoimmunity
F Ramírez-Valle, JC Maranville, S Roy… - Nature Reviews Drug …, 2024 - nature.com
Despite major progress in the treatment of autoimmune diseases in the past two decades,
most therapies do not cure disease and can be associated with increased risk of infection …
most therapies do not cure disease and can be associated with increased risk of infection …
Treating human autoimmunity: current practice and future prospects
MD Rosenblum, IK Gratz, JS Paw… - Science translational …, 2012 - science.org
Autoimmune diseases are caused by immune cells attacking the host tissues they are
supposed to protect. Recent advances suggest that maintaining a balance of effector and …
supposed to protect. Recent advances suggest that maintaining a balance of effector and …