Cellular senescence is now considered as a major mechanism in the development and
progression of various diseases and this may include metabolic diseases such as obesity …

Cellular senescence is the state of permanent inhibition of cell proliferation. Senescent cells
are characterized by several features including increased activity of senescence-associated …

Cellular senescence is a cell fate that occurs in response to numerous types of stress and
can promote tissue repair or drive inflammation and disruption of tissue homeostasis …

In the last decades the prevalence of obesity has increased dramatically, and the worldwide
epidemic of obesity and related metabolic diseases has contributed to an increased interest …

Increased insulin resistance and impaired insulin secretion are significant characteristics
manifested by patients with type 2 diabetes mellitus (T2DM). The degree and extent of these …

Cell senescence is defined as a state of irreversible cell cycle arrest combined with DNA
damage and the induction of a senescence-associated secretory phenotype (SASP). This …

In mammals, aging is associated with accumulation of senescent cells. Stresses such as
telomere shortening and reactive oxygen species induce “cellular senescence”, which is …

Cellular senescence is a fundamental aging mechanism that has been implicated in many
age-related diseases and is a significant cause of tissue dysfunction. Accumulation of …

Cardiologists and most physicians believe that aging is an independent risk factor for human
atherosclerosis, whereas atherosclerosis is thought to be a characteristic feature of aging in …

Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in
longevity and age‐related metabolic dysfunction. Fat distribution and function change …