Migraine is a complicated neurological disorder affecting 6% of men and 18% of women
worldwide. Various mechanisms, including neuroinflammation, oxidative stress, altered …

Background The pathomechanisms underlying migraine are intricate and remain largely
unclear. Initially regarded as a neuronal disorder, migraine research primarily concentrated …

Migraine is a pervasive neurologic disease closely related to neurogenic inflammation. The
astrocytes and microglia in the central nervous system are vital in inducing neurogenic …

Migraine is a complex and debilitating neurological disease that affects 15% of the
population worldwide. It is defined by the presence of recurrent severe attacks of disabling …

Background The lower threshold of neuronal hyperexcitability has been correlated with
migraines for decades but as technology has progressed, it has now become conceivable to …

Migraine is the second most prevalent disorder in the world; yet, its underlying mechanisms
are still poorly understood. Cumulative studies have revealed pivotal roles of cerebral cortex …

Currently, migraine is treated mainly by targeting calcitonin gene-related peptides, although
the efficacy of this method is limited and new treatment strategies are desired …

Neurogenic inflammation, a well-defined pathophysiologial process is characterized by the
release of potent vasoactive neuropeptides, predominantly calcitonin gene-related peptide …

Chronic migraine is a common chronic daily headache featured by frequent headache
attacks with at least 15 headache days per month, which brings great disease burden to …

Migraine represents a central neural hypersensitivity. During an attack, migraine sufferers
can be hypersensitive to normal levels of sound, light, smell and movement. Sensory …