CD4+ T cells are ineffective in clearing a pulmonary infection with influenza type A virus in the absence of B cells

K Mozdzanowska, M Furchner, K Maiese, W Gerhard - Virology, 1997 - Elsevier
Recovery from influenza virus infection is dependent on T cell functions which can be
provided either by CD8 or CD4 T cells. To identify the functions involved in recovery …

Role of the B‐cell response in recovery of mice from primary influenza virus infection

W Gerhard, K Mozdzanowska, M Furchner… - Immunological …, 1997 - Wiley Online Library
Recovery from influenza virus infection has long been known to require an intact T‐cell
compartment. More recent studies revealed that CD8 and CD4Tcells can promote recovery …

Clearance of an Influenza A Virus by CD4+ T Cells Is Inefficient in the Absence of B Cells

DJ Topham, PC Doherty - Journal of virology, 1998 - Am Soc Microbiol
The primary CD8+ T-cell response protected most B-cell-deficient μMT mice against
intranasal infection with the HKx31 influenza A virus. Prior exposure did not prevent …

Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection.

MB Graham, VL Braciale, TJ Braciale - The Journal of experimental …, 1994 - rupress.org
T lymphocytes play a primary role in recovery from viral infections and in antiviral immunity.
Although viral-specific CD8+ and CD4+ T cells have been shown to be able to lyse virally …

Roles of CD4+ T-Cell-Independent and -Dependent Antibody Responses in the Control of Influenza Virus Infection: Evidence for Noncognate CD4+ T-Cell Activities …

K Mozdzanowska, M Furchner, D Zharikova… - Journal of …, 2005 - Am Soc Microbiol
Previous studies have indicated that B cells make a significant contribution to the resolution
of influenza virus infection. To determine how B cells participate in the control of the …

Th cell-deficient mice control influenza virus infection more effectively than Th-and B cell-deficient mice: evidence for a Th-independent contribution by B cells to virus …

K Mozdzanowska, K Maiese… - The Journal of …, 2000 - journals.aai.org
The notion that MHC class I-restricted CD8+ T (Tc) cells are capable of resolving
autonomously infections with influenza virus is based largely on studies testing virus strains …

Diminished Primary and Secondary Influenza Virus-Specific CD8+ T-Cell Responses in CD4-Depleted Ig−/− Mice

JM Riberdy, JP Christensen, K Branum… - Journal of …, 2000 - Am Soc Microbiol
Optimal expansion of influenza virus nucleoprotein (DbNP366)-specific CD8+ T cells
following respiratory challenge of naive Ig−/− μMT mice was found to require CD4+ T-cell …

Compromised Influenza Virus-Specific CD8+-T-Cell Memory in CD4+-T-Cell-Deficient Mice

GT Belz, D Wodarz, G Diaz, MA Nowak… - Journal of …, 2002 - Am Soc Microbiol
The primary influenza A virus-specific CD8+-T-cell responses measured by tetramer staining
of spleen, lymph node, and bronchoalveolar lavage (BAL) lymphocyte populations were …

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

BS Bender, T Croghan, L Zhang… - The Journal of …, 1992 - rupress.org
To investigate the role of CD8+ T lymphocytes in recovery from influenza pneumonia, we
used transgenic mice either homozygous (-/-) or heterozygous (+/-) for beta 2-microglobulin …

Immune CD4+ T cells promote the clearance of influenza virus from major histocompatibility complex class II-/-respiratory epithelium

DJ Topham, RA Tripp, SR Sarawar… - Journal of …, 1996 - Am Soc Microbiol
The experiments described establish that CD4+ T-cell-dependent effector mechanisms can
eliminate an H3N2 influenza A virus from lung cells that are unable to express class II major …