Large variability in the individual response to even the most-efficacious pain treatments is
observed clinically, which has led to calls for a more personalized, tailored approach to …

There is tremendous interpatient variability in the response to analgesic therapy (even for
efficacious treatments), which can be the source of great frustration in clinical practice. This …

Purpose Precision pain medicine focuses on employing methods to assess each patient
individually, identify their risk profile for disproportionate pain and/or the development of …

Chronic pain is a constantly recurring and persistent illness, presenting a formidable
healthcare challenge for patients and physicians alike. Current first‐line analgesics offer …

The topical review entitled “Must we reduce pain intensity to treat chronic pain?” by Sullivan
and Ballantyne makes a cogent and thoughtful case for the consideration of outcomes other …

Abstract Treatment of neuropathic pain remains inadequate despite the elucidation of
multiple pathophysiological mechanisms and the development of promising therapeutic …

Objective. To provide recommendations for the core outcome domains that should be
considered by investigators conducting clinical trials of the efficacy and effectiveness of …

Genomic variations influencing response to pharmacotherapy of pain are currently under
investigation. Drug-metabolizing enzymes represent a major target of ongoing research in …

Use of opioid analgesics for pain management has increased dramatically over the past
decade, with corresponding increases in negative sequelae including overdose and death …

When interpreting the results of randomized clinical trials (RCTs) of efficacious pain
treatments, it is commonly concluded that some patients have responded to treatment …