Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory infiltration
in association with demyelination in the central nervous system. Among the factors involved …

Experimental autoimmune encephalitis (EAE), an animal model of multiple sclerosis (MS),
provides significant insights into the mechanisms that initiate and drive autoimmunity. MS is …

Multiple sclerosis (MS) pathology is marked by the massive infiltration of myelin‐specific T
cells into the CNS. Hallmarks of T helper (Th) cells during active disease are pro …

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis
(EAE), are autoimmune demyelinating diseases of the central nervous system (CNS) …

Background Hypomethylation of the cathepsin Z locus has been proposed as an epigenetic
risk factor for multiple sclerosis (MS). Cathepsin Z is a unique lysosomal cysteine cathepsin …

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system. The
disease manifestation is associated with the proliferation and activation of lymphocytes and …

Background Disruption of the extracellular matrix at the blood–brain barrier (BBB) underpins
neuroinflammation in multiple sclerosis (MS). The degradation of extracellular matrix …

In experimental autoimmune encephalomyelitis (EAE), Th1 cells are responsible for disease
induction while Th2 cells can be protective. To address the mechanisms of this differential …

Due to the plasticity of IL-17-producing CD4 T cells (Th17 cells), a long-standing challenge
in studying Th17-driven autoimmune is the lack of specific surface marker to identify the …

CD4+ T cells, specifically Th cells (Th1 and Th17) and regulatory T cells (Tregs), play a
pivotal role in the pathogenesis of multiple sclerosis (MS), a demyelinating autoimmune …