Prior research establishing that bone interacts in coordination with the bone marrow
microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on …

Murine models of myeloid neoplasia show how leukemia infiltration alters the hematopoietic
stem cell (HSC) niche to reinforce malignancy at the expense of healthy hematopoiesis …

The bone marrow niche consists of stem and progenitor cells destined to become mature
cells such as haematopoietic elements, osteoblasts or adipocytes. Marrow cells, influenced …

Abstract Purpose of Review This review focuses on evidence highlighting the bidirectional
crosstalk between the hematopoietic stem cell (HSC) and their surrounding stromal cells …

Blood and bone are dynamic tissues that are continuously renewed throughout life. Early
observations based upon the proximity of bone and hematopoietic progenitor populations in …

Clonal hematopoiesis (CH) defines a premalignant state predominantly found in older
persons that increases the risk of developing hematologic malignancies and age-related …

The skeletal system, while characterized by a hard tissue component, is in fact an
extraordinarily dynamic system, with disparate functions ranging from structural support …

The bone marrow (BM) niche comprises multiple cell types that regulate hematopoietic
stem/progenitor cell (HSPC) migration out of the niche and into the circulation. Here, we …

The bone marrow cavity is essential for the proper development of the hematopoietic
system. In the last few decades, it has become clear that mesenchymal stem/progenitor cells …

Identifying and understanding the roles of all cells comprising the HSC niche coupled with
the development of better 3D imaging and 3D in-vitro mimicking of the HSC niche will …