[HTML][HTML] GPER agonist G1 suppresses neuronal apoptosis mediated by endoplasmic reticulum stress after cerebral ischemia/reperfusion injury
ZW Han, YC Chang, Y Zhou, H Zhang… - Neural regeneration …, 2019 - journals.lww.com
Studies have confirmed a strong association between activation of the endoplasmic
reticulum stress pathway and cerebral ischemia/reperfusion (I/R) injury. In this study, three …
reticulum stress pathway and cerebral ischemia/reperfusion (I/R) injury. In this study, three …
[HTML][HTML] G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications …
N Bai, Q Zhang, W Zhang, B Liu, F Yang… - Journal of …, 2020 - Springer
Background G-protein-coupled estrogen receptor (GPER/GPR30) is a novel membrane-
associated estrogen receptor that can induce rapid kinase signaling in various cells …
associated estrogen receptor that can induce rapid kinase signaling in various cells …
17β-oestradiol alleviates endoplasmic reticulum stress injury induced by chronic cerebral hypoperfusion through the Haemoglobin/HIF 1α signalling pathway in …
C Xu, Y Dai, J Bai, B Ren, J Xu, F Gao, L Wang… - Neurochemistry …, 2021 - Elsevier
Endoplasmic reticulum stress (ERS) is known to be an essential target in protecting against
ischaemic brain injury. In this study, using a vascular dementia (VaD) animal model induced …
ischaemic brain injury. In this study, using a vascular dementia (VaD) animal model induced …
Activation of GPER-1 attenuates traumatic brain injury-induced neurological impairments in mice
Y Xue, Y Zhang, Y Wu, T Zhao - Molecular Neurobiology, 2024 - Springer
This study aimed to investigate the effects of G1-activated G protein-coupled estrogen
receptor 1 (GPER1) on neurological impairments and neuroinflammation in traumatic brain …
receptor 1 (GPER1) on neurological impairments and neuroinflammation in traumatic brain …
Activation of G-protein coupled estrogen receptor 1 improves early-onset cognitive impairment via PI3K/Akt pathway in rats with traumatic brain injury
ZF Wang, ZY Pan, CS Xu, ZQ Li - Biochemical and biophysical research …, 2017 - Elsevier
Previous studies experimentally reveal that G-protein coupled estrogen receptor 1 (GPER)
has neuroprotection against ischemic injury. However, its effect on traumatic brain injury …
has neuroprotection against ischemic injury. However, its effect on traumatic brain injury …
Effects of estrogen receptor GPR30 agonist G1 on neuronal apoptosis and microglia polarization in traumatic brain injury rats
MX Pan, JC Tang, R Liu, YG Feng… - Chinese Journal of …, 2018 - mednexus.org
Purpose: To investigate the effects of estrogen G protein-coupled receptor 30 (GPR30)
agonist G1 on hippocampal neuronal apoptosis and microglial polarization in rat traumatic …
agonist G1 on hippocampal neuronal apoptosis and microglial polarization in rat traumatic …
[HTML][HTML] Estrogen replacement therapy-induced neuroprotection against brain ischemia-reperfusion injury involves the activation of astrocytes via estrogen receptor β
Y Ma, H Guo, L Zhang, L Tao, A Yin, Z Liu, Y Li… - Scientific reports, 2016 - nature.com
The incidence of ischemic stroke is significantly increased in postmenopausal women.
However, the neuroprotective effects of estrogen replacement therapy (ERT) against stroke …
However, the neuroprotective effects of estrogen replacement therapy (ERT) against stroke …
[HTML][HTML] Estrogen and propofol combination therapy inhibits endoplasmic reticulum stress and remarkably attenuates cerebral ischemia-reperfusion injury and OGD …
F Xu, R Ma, G Zhang, S Wang, J Yin, E Wang… - Biomedicine & …, 2018 - Elsevier
Aim Endoplasmic reticulum stress (ERS) is vital in inducing apoptosis via caspase-12 and
C/EBP homologous protein (CHOP) apoptotic pathway in the hippocampus after ischemia …
C/EBP homologous protein (CHOP) apoptotic pathway in the hippocampus after ischemia …
17beta-estradiol attenuates programmed cell death in cortical pericontusional zone following traumatic brain injury via upregulation of ERalpha and inhibition of …
LZ Li, YJ Bao, M Zhao - Neurochemistry international, 2011 - Elsevier
Pericontusional zone (PCZ) of traumatic cerebral contusion is a target of pharmacological
intervention. It is well studied that 17beta-estradiol has a protective role in ischemic brain …
intervention. It is well studied that 17beta-estradiol has a protective role in ischemic brain …
Coupling of GPR30 mediated neurogenesis and protection with astroglial Aromatase-STAT3 signaling in rat hippocampus after global cerebral ischemia
L Wang, J Liu, J Xu, W Zhang, R Wang - Molecular and Cellular …, 2021 - Elsevier
Our previous study revealed that G-protein-coupled estrogen receptor-30 (GPR30) agonist
G1 serves as a viable alternative neuroprotectant of 17β-estradiol (E2) to attenuate …
G1 serves as a viable alternative neuroprotectant of 17β-estradiol (E2) to attenuate …
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