Image‐guided, percutaneous cryothermal ablation has become a critical modality for the
treatment of a variety of malignant and non‐malignant indications. This minimally invasive …

Cryoablation refers to all methods of destroying tissue by freezing [1]. Cryoablation can be
performed via surgical (open or laparoscopic) or percutaneous approaches. Percutaneous …

Clinically-based cryoablation, grounded on well-recognized scientific principles along with
the use of multiprobe devices and advanced imaging techniques, has experienced a rebirth …

Cryoablation refers to all methods of destroying tissue by freezing. Cryoablation causes
cellular damage, death, and necrosis of tissues by direct mechanisms, which cause cold …

Once requiring surgery, cryoablation now can be performed percutanously under image
guidance, thanks to the development of small probes. Sonography was used to guide …

The physical and biologic principles of localized high-temperature thermal therapy are well
understood. If the targeted tissue volume is heated beyond 57 to 60 C, the threshold for …

While the destructive actions of a cryoablative freeze cycle are long recognized, more recent
evidence has revealed a complex set of molecular responses that provides a path for …

A cryoablative freeze cycle has proven to be both physically destructive and to activate gene‐
regulated cell death cascades, which assure patient outcomes at least equivalent to other …

Purpose: Develop a new combination therapy consisting of cryoablation and conductive
high-temperature ablation for enhanced thermal ablation of solid tumors. Methods: We have …

Percutaneous imaging-guided cryoablation (PICA) is a recently developed technique, which
applies extreme hypothermia to destroy tumours under close imaging surveillance. It is …