Depressive disorders (DDs) are an increasingly common health problem that affects all age
groups. DDs pathogenesis is multifactorial. However, it was proven that stress is one of the …

Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Typically the monoamine system has been the central focus of neurobiological research into
depression and represents the major target of modern antidepressant medications; although …

This article presents a mechanism of action hypothesis to explain the rapid antidepressant
effects of esmethadone (REL-1017) and other uncompetitive N-methyl-D-aspartate receptor …

Major depressive disorder (MDD) is a common neuropsychiatric disorder affecting the mood
and mental well-being. Its pathophysiology remains elusive due to the complexity and …

Depression is one of the most common psychiatric conditions affecting numerous individuals
in the world. However, the currently available antidepressant medication shows low …

Depression is a mental illness that has a serious negative impact on physical and mental
health. The pathophysiology of depression is still unknown, and therapeutic medications …

Pharmacological and anatomical evidence suggests that abnormal glutamatergic
neurotransmission may be associated with the pathophysiology of depression. Compounds …

Major depressive disorder (MDD) affects approximately 121 million individuals globally and
poses a significant burden to the healthcare system. Around 50–60% of patients with MDD …

Major depressive disorder (MDD), also known as unipolar depression, is one of the leading
causes of disability and disease worldwide. The signs and symptoms are low self‑esteem …