Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation
A Dolganiuc, S Oak, K Kodys, DT Golenbock… - Gastroenterology, 2004 - Elsevier
Background & Aims: Recent evidence suggests that toll-like receptors (TLRs) recognize
certain viruses. We reported that hepatitis C virus (HCV) core and nonstructural 3 (NS3) …
certain viruses. We reported that hepatitis C virus (HCV) core and nonstructural 3 (NS3) …
Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins
S Chang, A Dolganiuc, G Szabo - Journal of Leucocyte Biology, 2007 - academic.oup.com
Hepatitis C virus (HCV) is a leading cause of end-stage liver disease through sustained
inflammation of the liver produced by the host's immune system. The mechanism for HCV …
inflammation of the liver produced by the host's immune system. The mechanism for HCV …
Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines
T Abe, Y Kaname, I Hamamoto, Y Tsuda, X Wen… - Journal of …, 2007 - Am Soc Microbiol
Hepatitis C virus (HCV) infection induces a wide range of chronic liver injuries; however, the
mechanism through which HCV evades the immune surveillance system remains obscure …
mechanism through which HCV evades the immune surveillance system remains obscure …
Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6
K Machida, KTH Cheng, VMH Sung, AM Levine… - Journal of …, 2006 - Am Soc Microbiol
Hepatitis C virus (HCV) induces inflammatory signals, leading to hepatitis, hepatocellular
carcinomas, and lymphomas. The mechanism of HCV involvement in the host's innate …
carcinomas, and lymphomas. The mechanism of HCV involvement in the host's innate …
[HTML][HTML] Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection
A Dolganiuc, C Garcia, K Kodys… - World journal of …, 2006 - ncbi.nlm.nih.gov
AIM: Hepatitis C virus often establishes chronic infections. Recent studies suggest that viral
and bacterial infections are more common in HCV-infected patients compared to controls …
and bacterial infections are more common in HCV-infected patients compared to controls …
Hepatitis C virus core and nonstructural protein 3 proteins induce pro-and anti-inflammatory cytokines and inhibit dendritic cell differentiation
A Dolganiuc, K Kodys, A Kopasz… - The Journal of …, 2003 - journals.aai.org
Antiviral immunity requires recognition of viral pathogens and activation of cytotoxic and Th
cells by innate immune cells. In this study, we demonstrate that hepatitis C virus (HCV) core …
cells by innate immune cells. In this study, we demonstrate that hepatitis C virus (HCV) core …
Expression of Toll‐like receptors in chronic hepatitis C virus infection
K Sato, T Ishikawa, A Okumura… - Journal of …, 2007 - Wiley Online Library
Abstract Background: Toll‐like receptors (TLRs) are involved in innate immunity. Certain
viruses interact with TLRs and mediate antiviral effects as well as immune responses. The …
viruses interact with TLRs and mediate antiviral effects as well as immune responses. The …
[PDF][PDF] Activation of chemokine and inflammatory cytokine response in hepatitis C virus–infected hepatocytes depends on toll‐like receptor 3 sensing of hepatitis C …
Chemokines and inflammatory cytokines are key regulators of immunity and inflammation
during viral infections. Hepatitis C virus (HCV) is a hepatotropic RNA virus frequently …
during viral infections. Hepatitis C virus (HCV) is a hepatotropic RNA virus frequently …
Toll-like receptor expression in chronic hepatitis C: correlation with pro-inflammatory cytokine levels and liver injury
SM Riordan, NA Skinner, J Kurtovic, S Locarnini… - Inflammation …, 2006 - Springer
Background/Aims Toll-like receptors (TLR's) are critical receptors that promote innate
immune responses to pathogen-associated molecular patterns. Activation of TLR's leads to …
immune responses to pathogen-associated molecular patterns. Activation of TLR's leads to …
[PDF][PDF] Impaired expression and function of toll‐like receptor 7 in hepatitis C virus infection in human hepatoma cells
S Chang, K Kodys, G Szabo - Hepatology, 2010 - Wiley Online Library
Hepatitis C virus (HCV) interferes with interferon (IFN)‐mediated innate immune defenses.
Toll‐like receptor (TLR) 7 agonists robustly inhibit HCV infection. We hypothesize that HCV …
Toll‐like receptor (TLR) 7 agonists robustly inhibit HCV infection. We hypothesize that HCV …