Metastasis of breast cancer, especially to the brain, is the major cause of mortality. The
inability of anticancer agents to cross the blood-brain-barrier represents a critical challenge …

Triple negative breast cancer (TNBC) patients have a high risk of brain metastases. This
deadly disease represents a major challenge for successful treatment, in part because of the …

Women with aggressive triple-negative breast cancer (TNBC) are at high risk of brain
metastasis, which has no effective therapeutic option partially due to the poor penetration of …

Epidemiological observations have shown that schizophrenia patients after long-term drug
treatment exhibited reduced tumor incidences. The potential anticancer effects of …

Glioblastoma (GBM) is the most common brain tumor with poor survival rate. Our results
show that penfluridol, an antipsychotic drug significantly reduced the survival of ten adult …

Because cancer cell invasion is a critical determinant of metastasis, targeting invasion is a
viable approach to prevent metastasis. Utilizing a novel three-dimensional high-throughput …

Penfluridol has robust antipsychotic efficacy and is a first-generation diphenylbutylpiperidine
. Its effects last for several days after a single oral dose and it can be administered once a …

The recent development of high throughput compound screening has allowed drug
repurposing to emerge as an effective avenue for discovering novel treatments for cancer …

Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer and still
lacks available targeted therapy options. Thioridazine hydrochloride (Thi-hyd), a common …

Among breast cancer patients, metastases are the leading cause of death. Despite decades
of effort, little progress has been made to improve the treatment of breast cancer metastases …