The central role of the gut in intensive care

A Corriero, RM Gadaleta, F Puntillo, F Inchingolo… - Critical Care, 2022 - Springer
Critically ill patients undergo early impairment of their gut microbiota (GM) due to routine
antibiotic therapies and other environmental factors leading to intestinal dysbiosis. The GM …

The central and biodynamic role of gut microbiota in critically ill patients

H Wozniak, TS Beckmann, L Fröhlich, T Soccorsi… - Critical Care, 2022 - Springer
Gut microbiota plays an essential role in health and disease. It is constantly evolving and in
permanent communication with its host. The gut microbiota is increasingly seen as an organ …

The gut microbiota of critically ill patients: first steps in an unexplored world

É Ruppé, T Lisboa, F Barbier - Intensive Care Medicine, 2018 - Springer
The gut microbiota is a complex ecosystem encompassing all bacteria, fungi, archaea,
viruses, and protozoa that colonize the intestinal tract, reaching in healthy humans an …

Gut microbiota and host defense in critical illness

MC Jacobs, BW Haak, F Hugenholtz… - Current opinion in …, 2017 - journals.lww.com
In health, a diverse microbiome might enhance host defense, while during critical illness, the
dysbiotic microbiome might contribute to comorbidity and organ dysfunction. Future research …

The intestinal microbiota and host immune interactions in the critically ill

TJ Schuijt, T van der Poll, WM de Vos… - Trends in microbiology, 2013 - cell.com
The gastrointestinal tract harbors a complex population of microbes that play a fundamental
role in the development of the immune system and human health. Besides an important …

Gut Microbiota and Critically Ill Patients: Immunity and Its Modulation via Probiotics and Immunonutrition

L Abenavoli, E Scarpellini, MR Paravati, GGM Scarlata… - Nutrients, 2023 - mdpi.com
Critically ill patients have a hyper-inflammatory response against various offending injuries
that can result in tissue damage, organ failure, and fatal prognosis. The origin of this …

Blurred lines: dysbiosis and probiotics in the ICU

LE Morrow, P Wischmeyer - Chest, 2017 - Elsevier
Clinicians have traditionally dichotomized bacteria as friendly commensals or harmful
pathogens. However, the line separating the two has become blurred with the recognition …

Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death

R Xu, C Tan, J Zhu, X Zeng, X Gao, Q Wu, Q Chen… - Critical Care, 2019 - Springer
Background Despite the essential functions of the intestinal microbiota in human physiology,
little has been reported about the microbiome in neurocritically ill patients. This investigation …

Gut microbiota in surgical and critically ill patients

KM Ho, S Kalgudi, JM Corbett… - … and Intensive Care, 2020 - journals.sagepub.com
Microbiota—defined as a collection of microbial organisms colonising different parts of the
human body—is now recognised as a pivotal element of human health, and explains a large …

The gut microbiome's role in the development, maintenance, and outcomes of sepsis

MW Adelman, MH Woodworth, C Langelier, LM Busch… - Critical care, 2020 - Springer
The gut microbiome regulates a number of homeostatic mechanisms in the healthy host
including immune function and gut barrier protection. Loss of normal gut microbial structure …