IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
X Chang, YM Tan, DG Allen, S Bell, PC Brown… - Toxics, 2022 - mdpi.com
During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …
transformation from observational to predictive science. New approach methodologies …
In vitro to in vivo extrapolation for high throughput prioritization and decision making
SM Bell, X Chang, JF Wambaugh, DG Allen, M Bartels… - Toxicology in vitro, 2018 - Elsevier
In vitro chemical safety testing methods offer the potential for efficient and economical tools
to provide relevant assessments of human health risk. To realize this potential, methods are …
to provide relevant assessments of human health risk. To realize this potential, methods are …
Developing context appropriate toxicity testing approaches using new alternative methods (NAMs)
ME Andersen, PD McMullen, MB Phillips… - ALTEX-Alternatives to …, 2019 - altex.org
In the past 10 years, the public, private, and non-profit sectors have found agreement that
hazard identification and risk assessment should capitalize on the explosion of knowledge …
hazard identification and risk assessment should capitalize on the explosion of knowledge …
A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment
KA Magurany, X Chang, R Clewell… - Toxicological …, 2023 - academic.oup.com
Globally, industries and regulatory authorities are faced with an urgent need to assess the
potential adverse effects of chemicals more efficiently by embracing new approach …
potential adverse effects of chemicals more efficiently by embracing new approach …
Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework
RS Thomas, MA Philbert, SS Auerbach… - toxicological …, 2013 - academic.oup.com
Based on existing data and previous work, a series of studies is proposed as a basis toward
a pragmatic early step in transforming toxicity testing. These studies were assembled into a …
a pragmatic early step in transforming toxicity testing. These studies were assembled into a …
The role of in vitro methods as alternatives to animals in toxicity testing
A Anadón, MA Martínez, V Castellano… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: It is accepted that animal testing should be reduced, refined or replaced as far
as it is practicably possible. There are also a wide variety of in vitro models, which are used …
as it is practicably possible. There are also a wide variety of in vitro models, which are used …
A framework for chemical safety assessment incorporating new approach methodologies within REACH
N Ball, R Bars, PA Botham, A Cuciureanu… - Archives of …, 2022 - Springer
The long-term investment in new approach methodologies (NAMs) within the EU and other
parts of the world is beginning to result in an emerging consensus of how to use information …
parts of the world is beginning to result in an emerging consensus of how to use information …
Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi
F Caloni, I De Angelis, T Hartung - Archives of Toxicology, 2022 - Springer
Alternative methods to animal use in toxicology are evolving with new advanced tools and
multilevel approaches, to answer from one side to 3Rs requirements, and on the other side …
multilevel approaches, to answer from one side to 3Rs requirements, and on the other side …
Workshop overview: scientific and regulatory challenges for the reduction, refinement, and replacement of animals in toxicity testing
IFH Purchase, PA Botham, LH Bruner, OP Flint… - Toxicological …, 1998 - Elsevier
Public concern for animal welfare has been expressed through legislative control of animal
use for experimental purposes since the first legislation was introduced in 1876 in the United …
use for experimental purposes since the first legislation was introduced in 1876 in the United …
[HTML][HTML] The role of validation in establishing the scientific credibility of predictive toxicology approaches intended for regulatory application
New approaches in toxicology based on in vitro methods and computational modelling offer
considerable potential to improve the efficiency and effectiveness of chemical hazard and …
considerable potential to improve the efficiency and effectiveness of chemical hazard and …