Expert consultation is vital for adverse outcome pathway development: a case example of cardiovascular effects of ionizing radiation
V Chauhan, N Hamada, V Monceau… - … Journal of Radiation …, 2021 - Taylor & Francis
Background The circulatory system distributes nutrients, signaling molecules, and immune
cells to vital organs and soft tissues. Epidemiological, animal, and in vitro cellular …
cells to vital organs and soft tissues. Epidemiological, animal, and in vitro cellular …
Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease
O Azimzadeh, S Moertl, R Ramadan… - … Journal of Radiation …, 2022 - Taylor & Francis
Background Epidemiological studies have indicated that exposure of the heart to doses of
ionizing radiation as low as 0.5 Gy increases the risk of cardiac morbidity and mortality with …
ionizing radiation as low as 0.5 Gy increases the risk of cardiac morbidity and mortality with …
Radiation adverse outcome pathways (AOPs) are on the horizon: advancing radiation protection through an international Horizon-Style exercise
JJ Burtt, J Leblanc, K Randhawa… - … Journal of Radiation …, 2022 - Taylor & Francis
Abstract Purpose The Adverse Outcome Pathway (AOP) framework, a systematic tool that
can link available mechanistic data with phenotypic outcomes of relevance to regulatory …
can link available mechanistic data with phenotypic outcomes of relevance to regulatory …
Collaborative efforts are needed among the scientific community to advance the adverse outcome pathway concept in areas of radiation risk assessment
V Chauhan, D Villeneuve, D Cool - International journal of …, 2021 - Taylor & Francis
Disease prevention and prediction have led to the generation of phenotypically based
methods for deriving the limits of safety across toxicological disciplines. In the ionizing …
methods for deriving the limits of safety across toxicological disciplines. In the ionizing …
Adverse outcome pathway: a path toward better data consolidation and global co-ordination of radiation research
V Chauhan, D Beaton, N Hamada… - … Journal of Radiation …, 2022 - Taylor & Francis
Background The purpose of toxicology is to protect human health and the environment. To
support this, the Organisation for Economic Co-operation and Development (OECD) …
support this, the Organisation for Economic Co-operation and Development (OECD) …
The integration of the adverse outcome pathway framework to radiation risk assessment
V Chauhan, D Stricklin, D Cool - International Journal of Radiation …, 2021 - Taylor & Francis
Background A large body of radiobiological data has been generated over the past century
using in vitro, animal and epidemiological models. This information represents global efforts …
using in vitro, animal and epidemiological models. This information represents global efforts …
Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework
V Chauhan, RC Wilkins, D Beaton… - … journal of radiation …, 2021 - Taylor & Francis
Background Decades of research to understand the impacts of various types of
environmental occupational and medical stressors on human health have produced a vast …
environmental occupational and medical stressors on human health have produced a vast …
Integrating basic radiobiological science and epidemiological studies: why and how
RJ Preston - Health Physics, 2015 - journals.lww.com
There is quite an extensive set of epidemiology studies conducted for a range of different
radiation exposure scenarios and in some cases at doses that can be considered to be in …
radiation exposure scenarios and in some cases at doses that can be considered to be in …
Establishing a communication and engagement strategy to facilitate the adoption of the adverse outcome pathways in radiation research and regulation
V Chauhan, N Hamada, J Garnier-Laplace… - … journal of radiation …, 2022 - Taylor & Francis
Background Studies on human health and ecological effects of ionizing radiation are rapidly
evolving as innovative technologies arise and the body of scientific knowledge grows …
evolving as innovative technologies arise and the body of scientific knowledge grows …
Is there a role for the adverse outcome pathway framework to support radiation protection?
V Chauhan, Z Said, J Daka, B Sadi… - … Journal of Radiation …, 2019 - Taylor & Francis
Abstract Purpose: In 2012, the Organization for Economic Cooperation and Development
(OECD) formally launched the Adverse Outcome Pathway (AOP) Programme. The AOP …
(OECD) formally launched the Adverse Outcome Pathway (AOP) Programme. The AOP …