Entorhinal cortex dysfunction in Alzheimer's disease
KM Igarashi - Trends in neurosciences, 2023 - cell.com
The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …
Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease
OJ Olajide, ME Suvanto, CA Chapman - Biology Open, 2021 - journals.biologists.com
The entorhinal cortex (EC) is a vital component of the medial temporal lobe, and its
contributions to cognitive processes and memory formation are supported through its …
contributions to cognitive processes and memory formation are supported through its …
Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease
The entorhinal cortex has been implicated in the early stages of Alzheimer's disease, which
is characterized by changes in the tau protein and in the cleaved fragments of the amyloid …
is characterized by changes in the tau protein and in the cleaved fragments of the amyloid …
Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer's disease mouse model
C Criscuolo, V Fontebasso, S Middei, M Stazi… - Scientific reports, 2017 - nature.com
The Entorhinal cortex (EC) has been implicated in the early stages of Alzheimer's disease
(AD). In particular, spreading of neuronal dysfunction within the EC-Hippocampal network …
(AD). In particular, spreading of neuronal dysfunction within the EC-Hippocampal network …
Functional imbalance of anterolateral entorhinal cortex and hippocampal dentate/CA3 underlies age-related object pattern separation deficits
ZM Reagh, JA Noche, NJ Tustison, D Delisle… - Neuron, 2018 - cell.com
The entorhinal cortex (EC) is among the earliest brain areas to deteriorate in Alzheimer's
disease (AD). However, the extent to which functional properties of the EC are altered in the …
disease (AD). However, the extent to which functional properties of the EC are altered in the …
Entorhinal cortex: a good biomarker of mild cognitive impairment and mild Alzheimer's disease
M Zhou, F Zhang, L Zhao, J Qian… - Reviews in the …, 2016 - degruyter.com
Entorhinal cortex (EC), thought to be the location of the earliest lesions in Alzheimer's
disease (AD), has been widely studied in recent years. With the irreversible pathological …
disease (AD), has been widely studied in recent years. With the irreversible pathological …
Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease
A von Gunten, E Kövari, T Bussière, CB Rivara… - Neurobiology of …, 2006 - Elsevier
The relative contribution of Alzheimer's disease (AD) hippocampal neuronal pathology in
cognitive decline is still a matter of debate. To address this issue, we performed a …
cognitive decline is still a matter of debate. To address this issue, we performed a …
Selective vulnerability of neurons in layer II of the entorhinal cortex during aging and Alzheimer′ s disease
AM Stranahan, MP Mattson - Neural plasticity, 2010 - Wiley Online Library
All neurons are not created equal. Certain cell populations in specific brain regions are more
susceptible to age‐related changes that initiate regional and system‐level dysfunction. In …
susceptible to age‐related changes that initiate regional and system‐level dysfunction. In …
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
T Gómez-Isla, JL Price, DW McKeel Jr… - Journal of …, 1996 - Soc Neuroscience
The entorhinal cortex (EC) plays a crucial role as a gateway connecting the neocortex and
the hippocampal formation. Layer II of the EC gives rise to the perforant pathway, the major …
the hippocampal formation. Layer II of the EC gives rise to the perforant pathway, the major …
Perturbations of neural circuitry in aging, mild cognitive impairment, and Alzheimer's disease
Alzheimer's disease (AD) is a global public health threat that continues to rise as the
proportion of the population over the age of 60 rapidly increases. Aging and dementia are …
proportion of the population over the age of 60 rapidly increases. Aging and dementia are …
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