A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation
The mutualistic relationship of gut-resident microbiota and the host immune system
promotes homeostasis that ensures maintenance of the microbial community and of a …
promotes homeostasis that ensures maintenance of the microbial community and of a …
[HTML][HTML] Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota
B Akagbosu, Z Tayyebi, G Shibu, YA Paucar Iza… - Nature, 2022 - nature.com
Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital
for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells …
for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells …
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut
Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell
responses, but the mechanisms controlling these distinct outcomes remain poorly …
responses, but the mechanisms controlling these distinct outcomes remain poorly …
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont
Both microbial and host genetic factors contribute to the pathogenesis of autoimmune
diseases,,,. There is accumulating evidence that microbial species that potentiate chronic …
diseases,,,. There is accumulating evidence that microbial species that potentiate chronic …
Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota
Peripheral mechanisms preventing autoimmunity and maintaining tolerance to commensal
microbiota involve CD4+ Foxp3+ regulatory T (Treg) cells, generated in the thymus or …
microbiota involve CD4+ Foxp3+ regulatory T (Treg) cells, generated in the thymus or …
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
Innate lymphoid cells (ILCs) are a recently characterized family of immune cells that have
critical roles in cytokine-mediated regulation of intestinal epithelial cell barrier integrity …
critical roles in cytokine-mediated regulation of intestinal epithelial cell barrier integrity …
Peripheral education of the immune system by colonic commensal microbiota
The instruction of the immune system to be tolerant of self, thereby preventing autoimmunity,
is facilitated by the education of T cells in a specialized organ, the thymus, in which self …
is facilitated by the education of T cells in a specialized organ, the thymus, in which self …
A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells
CSN Klose, EA Kiss, V Schwierzeck, K Ebert, T Hoyler… - Nature, 2013 - nature.com
At mucosal surfaces, the immune system should not initiate inflammatory immune responses
to the plethora of antigens constantly present in the environment, but should remain poised …
to the plethora of antigens constantly present in the environment, but should remain poised …
Thymic development of gut-microbiota-specific T cells
Humans and their microbiota have coevolved a mutually beneficial relationship in which the
human host provides a hospitable environment for the microorganisms and the microbiota …
human host provides a hospitable environment for the microorganisms and the microbiota …
Extrathymically generated regulatory T cells control mucosal TH2 inflammation
A balance between pro-and anti-inflammatory mechanisms at mucosal interfaces, which are
sites of constitutive exposure to microbes and non-microbial foreign substances, allows for …
sites of constitutive exposure to microbes and non-microbial foreign substances, allows for …