Comprehensive identification of RNA-binding domains in human cells

A Castello, B Fischer, CK Frese, R Horos, AM Alleaume… - Molecular cell, 2016 - cell.com
Mammalian cells harbor more than a thousand RNA-binding proteins (RBPs), with half of
these employing unknown modes of RNA binding. We developed RBDmap to determine the …

A brave new world of RNA-binding proteins

MW Hentze, A Castello, T Schwarzl… - Nature reviews Molecular …, 2018 - nature.com
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …

Sequence, structure, and context preferences of human RNA binding proteins

D Dominguez, P Freese, MS Alexis, A Su, M Hochman… - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …

RNA-binding proteins in Mendelian disease

A Castello, B Fischer, MW Hentze, T Preiss - Trends in Genetics, 2013 - cell.com
RNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function
underlie a broad spectrum of human pathologies. We focus here on two recent studies that …

EuRBPDB: a comprehensive resource for annotation, functional and oncological investigation of eukaryotic RNA binding proteins (RBPs)

JY Liao, B Yang, YC Zhang, XJ Wang, Y Ye… - Nucleic acids …, 2020 - academic.oup.com
RNA binding proteins (RBPs) are a large protein family that plays important roles at almost
all levels of gene regulation through interacting with RNAs, and contributes to numerous …

RNA-binding proteins in human genetic disease

F Gebauer, T Schwarzl, J Valcárcel… - Nature Reviews …, 2021 - nature.com
RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …

Deciphering human ribonucleoprotein regulatory networks

N Mukherjee, HH Wessels, S Lebedeva… - Nucleic acids …, 2019 - academic.oup.com
RNA-binding proteins (RBPs) control and coordinate each stage in the life cycle of RNAs.
Although in vivo binding sites of RBPs can now be determined genome-wide, most studies …

High-throughput characterization of protein–RNA interactions

KB Cook, TR Hughes, QD Morris - Briefings in functional …, 2015 - academic.oup.com
RNA-binding proteins (RBPs) are important regulators of eukaryotic gene expression.
Genomes typically encode dozens to hundreds of proteins containing RNA-binding …

Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease

S Gerstberger, M Hafner, M Ascano… - Systems biology of RNA …, 2014 - Springer
RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene
regulation (PTGR). RBPs regulate stability, maturation, and turnover of all RNAs, often …

Resources for the comprehensive discovery of functional RNA elements

B Sundararaman, L Zhan, SM Blue, R Stanton, K Elkins… - Molecular cell, 2016 - cell.com
Transcriptome-wide maps of RNA binding protein (RBP)-RNA interactions by
immunoprecipitation (IP)-based methods such as RNA IP (RIP) and crosslinking and IP …