Comprehensive identification of RNA-binding domains in human cells
Mammalian cells harbor more than a thousand RNA-binding proteins (RBPs), with half of
these employing unknown modes of RNA binding. We developed RBDmap to determine the …
these employing unknown modes of RNA binding. We developed RBDmap to determine the …
A brave new world of RNA-binding proteins
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …
Sequence, structure, and context preferences of human RNA binding proteins
D Dominguez, P Freese, MS Alexis, A Su, M Hochman… - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
RNA-binding proteins in Mendelian disease
RNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function
underlie a broad spectrum of human pathologies. We focus here on two recent studies that …
underlie a broad spectrum of human pathologies. We focus here on two recent studies that …
EuRBPDB: a comprehensive resource for annotation, functional and oncological investigation of eukaryotic RNA binding proteins (RBPs)
JY Liao, B Yang, YC Zhang, XJ Wang, Y Ye… - Nucleic acids …, 2020 - academic.oup.com
RNA binding proteins (RBPs) are a large protein family that plays important roles at almost
all levels of gene regulation through interacting with RNAs, and contributes to numerous …
all levels of gene regulation through interacting with RNAs, and contributes to numerous …
RNA-binding proteins in human genetic disease
RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …
malfunction underlies the origin of many diseases. RBPs can recognize hundreds of …
Deciphering human ribonucleoprotein regulatory networks
RNA-binding proteins (RBPs) control and coordinate each stage in the life cycle of RNAs.
Although in vivo binding sites of RBPs can now be determined genome-wide, most studies …
Although in vivo binding sites of RBPs can now be determined genome-wide, most studies …
High-throughput characterization of protein–RNA interactions
RNA-binding proteins (RBPs) are important regulators of eukaryotic gene expression.
Genomes typically encode dozens to hundreds of proteins containing RNA-binding …
Genomes typically encode dozens to hundreds of proteins containing RNA-binding …
Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease
RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene
regulation (PTGR). RBPs regulate stability, maturation, and turnover of all RNAs, often …
regulation (PTGR). RBPs regulate stability, maturation, and turnover of all RNAs, often …
Resources for the comprehensive discovery of functional RNA elements
B Sundararaman, L Zhan, SM Blue, R Stanton, K Elkins… - Molecular cell, 2016 - cell.com
Transcriptome-wide maps of RNA binding protein (RBP)-RNA interactions by
immunoprecipitation (IP)-based methods such as RNA IP (RIP) and crosslinking and IP …
immunoprecipitation (IP)-based methods such as RNA IP (RIP) and crosslinking and IP …